The pathological physiology of heartwater [Cowdria (Rickettsia) ruminantium - Cowdry, 1926]

Show simple item record Clark, R.
dc.contributor.editor Jansen, B.C. 2016-07-11T09:28:50Z 2016-07-11T09:28:50Z 2016 1962
dc.description The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format. en_ZA
dc.description.abstract The pathological physiology of heartwater has been studied in acute, untreated fatal cases in sheep and cattle. No significant changes could be found in the blood constituents. The main findings were (a) disappearance of circulating eosinophiles; (b) sympatholysis manifested firstly by a fall in haematocrit readings due to splenic relaxation followed by a subterminal peripheral vaso-collapse with a dramatic fall in arterial diastolic pressure; and (c) a terminal catastrophic drop in plasma volume due to an increased capillary permeability which allows of the passage of plasma proteins from the vascular system. The use of sympathomimetics and intravenous infusions of packed red cells or whole blood are recommended as supportive treatment in advanced cases. The possible practical applications of the finding of the disappearance of the eosinophils prior to the onset of the febrile reaction will be investigated further. Three sheep showing collapse after having received chemotherapy late in the heartwater reaction were studied. These animals were showing general collapse. The condition is described as a functional decerebration with the vegetative functions of the body proceeding more or less normally. The cerebral damage would appear to be irreversible. en_ZA
dc.identifier.citation Clark, R 1962, 'The pathological physiology of heartwater [Cowdria (Rickett-sia) raminantium-Cowdry, 1926’, Onderstepoort Journal of Veterinary Research, vol. 29, no. 1, pp. 25-33. en_ZA
dc.identifier.issn 0330-2465
dc.language.iso en en_ZA
dc.publisher Pretoria : Government Printer en_ZA
dc.rights © 1962 ARC - Onderstepoort and Faculty of Veterinary Science, University of Pretoria (original). © 2016 University of Pretoria. Dept. of Library Services (digital). en_ZA
dc.subject Veterinary medicine en_ZA
dc.subject.lcsh Veterinary medicine -- South Africa
dc.title The pathological physiology of heartwater [Cowdria (Rickettsia) ruminantium - Cowdry, 1926] en_ZA
dc.type Article en_ZA

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