Glucose turnover, tolerance and insulin response in wethers, ewes and pregnant ewes in the fed and fasted state

Show simple item record Procos, J. Labuschagne, F.J. Van der Walt, J.G.
dc.contributor.editor Bigalke, R.D.
dc.contributor.editor Cameron, Colin McKenzie
dc.contributor.editor Gilchrist, Frances M.C.
dc.contributor.editor Morren, A.J.
dc.contributor.editor Verster, Anna J.M.
dc.contributor.editor Verwoerd, Daniel Wynand
dc.contributor.editor Walker, Jane B.
dc.contributor.other Steyn, P.J.J. 2016-07-07T08:28:25Z 2016-07-07T08:28:25Z 2016 1980
dc.description The articles have been scanned in colour with a HP Scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format. en_ZA
dc.description.abstract Glucose turnover parameters were obtained in fed and fasted wethers, ewes and pregnant ewes in their 2nd and 3rd trimesters, using a jugular bolus injection of D-glucose-2-³H. Fasting significantly (P<0,05) reduced glucose turnover (c. 40%) in both the wether and the non-pregnant ewe. A somewhat larger difference (c. 54%) between the fed and fasted ewes was found in their 3rd trimester of pregnancy due to an increase when fed (c. 29% higher turnover than in the non-pregnant ewe) rather than a decrease when fasted, since there was no statistical difference (P< 0, 1) between glucose turnover values of pregnant or non-pregnant fasted ewes. Glucose tolerance was estimated from an intrajugular glucose load (1 g/kg⁰'⁷⁵ body mass) in these 3 groups of sheep under both fed and fasted conditions, and the resulting insulin response was followed for 4 h after the injection. Fasting reduced the plasma clearance rate of glucose by c. 63% in both the wether and the nonpregnant ewe while the reduction was somewhat smaller (c. 51%) during the 2nd trimester of pregnancy. Only the pregnant ewe group showed a corresponding reduction in the resulting insulin response of 46% which was similar in magnitude to the diminished clearance, indicating that factors other than insulin are responsible for the reduced glucose clearance associated with fasting in the weather and non-pregnant ewe. Despite similar baseline plasma glucose values the glucose load appeared to distribute in a space that was significantly less than that found in all 3 groups of fed sheep when trace amounts were injected. en_ZA
dc.identifier.citation Van der Walt, JG, Procos, J & Labuschagne, FJ 1980, 'Glucose turnover, tolerance and insulin response in wethers, ewes and pregnant ewes in the fed and fasted state’, Onderstepoort Journal of Veterinary Research, vol. 47, no. 3, pp. 173-178. en_ZA
dc.identifier.issn 0330-2465
dc.language.iso en en_ZA
dc.publisher Published by the Government Printer, Pretoria. en_ZA
dc.rights ©1980 ARC - Onderstepoort and Faculty of Veterinary Science, University of Pretoria (original). ©2016 University of Pretoria Department of Library Services (digital). en_ZA
dc.subject Veterinary medicine en_ZA
dc.subject.lcsh Veterinary medicine -- South Africa
dc.title Glucose turnover, tolerance and insulin response in wethers, ewes and pregnant ewes in the fed and fasted state en_ZA
dc.type Article en_ZA

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