Stimulation of the immune response in vivo by different nucleic acids

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dc.contributor.author Oellermann, R.A.
dc.contributor.editor Bigalke, R.D.
dc.contributor.editor Cameron, Colin McKenzie
dc.contributor.editor Verster, Anna J.M.
dc.contributor.editor Walker, Jane B.
dc.contributor.other De Kock, V.E.
dc.date.accessioned 2016-07-06T12:42:36Z
dc.date.available 2016-07-06T12:42:36Z
dc.date.created 2016
dc.date.issued 1974
dc.description The articles have been scanned in colour with a HP Scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format. en_ZA
dc.description.abstract The number of haemolytic plaque forming cells (PFCs) in the spleens of normal mice could not be increased by the injection of nucleic acids. However, when nucleic acids were injected into mice simultaneously with a priming dose of 3 x 10⁶ sheep erythrocytes (SRBCs) an appreciable stimulatory effect was observed. The same dose of SRBCs did not result in an increase in PFCs when injected alone. Nucleic acids at a concentration of approximately 1.5 mg per mouse resulted in an optimal stimulation of the immune response. Treatment of the nucleic acids by ribonuclease and deoxyribonuclase essentially eliminated the stimulatory effect of the RNA and DNA respectively whereas incubation with trypsin did not. Administration of pure single stranded RNAs from the livers and spleens of both normal and immunized mice resulted in a greater increase in the number of PFCs than nucleic acids from other sources. The stimulation of PFCs by RNAs from immunized mice was slightly greater than by RNAs from non-immunized mice. The immune response was also activated if the nucleic acids and the priming dose of antigen were not injected simultaneously. en_ZA
dc.identifier.citation Oellermann, RA 1974, 'Stimulation of the immune response in vivo by different nucleic acids’, Onderstepoort Journal of Veterinary Research, vol. 41, no. 4, pp. 217-220. en_ZA
dc.identifier.issn 0330-2465
dc.identifier.uri http://hdl.handle.net/2263/53855
dc.language.iso en en_ZA
dc.publisher Pretoria : The Government Printer en_ZA
dc.rights ©1974 ARC - Onderstepoort and Faculty of Veterinary Science, University of Pretoria (original) ©2016 University of Pretoria. Department of Library Services (digital) en_ZA
dc.subject Veterinary medicine en_ZA
dc.subject.lcsh Veterinary medicine -- South Africa
dc.title Stimulation of the immune response in vivo by different nucleic acids en_ZA
dc.type Article en_ZA


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