Aetiology of jaagsiekte : experimental transmission to lambs by means of cultured cells and cell homogenates

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Authors

Verwoerd, Daniel Wynand
De Villiers, Ethel-Michele
Tustin, R.C.

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Published by the Government Printer, Pretoria.

Abstract

Studies on the transmission of jaagsiekte (ovine pulmonary adenomatosis) both by sub inoculation of cells of known sex and by cell homogenates into male and female lambs are reported. The results obtained indicate a thymocyte-dependent rejection of male cells in female recipients in contrast to the successful transplantation of male cells in male animals and female cells in both sexes. This suggests the presence of a surface antigen determined by the Y-chromosome in the tumour cells. A second mechanism of transmission, dependent on the transformation of the recipient's cells, was demonstrated by 2 cases of heterologous transplantation and confirmed by inoculation of cellular homogenates

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Keywords

Veterinary medicine

Sustainable Development Goals

Citation

Verwoerd, DW, De Villiers, EM & Tustin, RC 1980, 'Etiology of Jaagsiekte - Experimental Transmission to Lambs by Means of Cultured-Cells and Cell Homogenates’, Onderstepoort Journal of Veterinary Research, vol. 47, no. 1, pp. 13-18.