Abstract:
A soluble protein antigen was prepared from Brucella melitensis Rev I with which macrophage migration inhibition (MMI) assays were successfully done using guinea-pig peritoneal exudate cells. By comparing the MMI, agglutinin response and immunity of groups and of individual guinea-pigs which had been immunized with either B. melitensis Rev I live vaccine or B. melitensis Rev I inactivated antigen, an association between the MMI and resistance to infection was demonstrated.
