Electron microscopic and serological studies carried out on Simian virus S.A. 11 and the O agent in MK2 cells have indicated that these viruses differ considerably. While S.A. 11 virus is associated with vesicles of the rough endoplasmic reticulum, with viral inclusion bodies and with membranous elements, O agent shows no such relationships but occurs in vacuoles and in crystalline array in the cytoplasmic matrix. No cross neutralization could be demonstrated.
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