The stimulation of interferon synthesis by bluetongue virus and by bluetongue virus ribonucleic acid was investigated in order to determine if there is a difference in the mechanism of induction. The molecular mass of the interferon formed after the two induction processes was determined using Sephadex gel filtration. A value of 24 000 was found in both cases. These results suggest that the two induction processes are basically similar and that double-stranded ribonucleic acid is the active inducing principle in both stimulating processes.
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