Composition and evaluation of the efficacy of a Staphylococcus aureus vaccine
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Authors
Cameron, Colin McKenzie
Fuls, W.J.P.
Botha, Wilna F.
Journal Title
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Volume Title
Publisher
Published by The Government Printer, Pretoria
Abstract
An alum-precipitated Staphylococcus aureus vaccine, composed of a formalin-inactivated whole culture of a strain which produces Smith surface antigen and combined with the whole culture of a highly toxigenic strain, was found to afford a good immunity to staphylococcal skin infection in rabbits.
Three injections of the vaccine provided immunity which lasted for at least 6 months against a primarily pyogenic strain of S. aureus and for at least 3 months against a toxigenic strain. From experiments using vaccines prepared from cells or toxoid only, it was deduced that, although there is a measure of strain specific immunity, a good heterologous immunity can be established with a combined product provided that it contains adequate quantities of toxoid. The use of such a vaccine as a potential aid in the control of bovine staphylococcal mastitis is discussed.
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Keywords
Veterinary medicine
Sustainable Development Goals
Citation
Cameron, CM, Fuls, WJP & Botha, WF 1979, 'Composition and evaluation of the efficacy of a Staphylococcus aureus vaccine.’, Onderstepoort Journal of Veterinary Research, vol. 46, no. 1, pp. 1-8.