Kafirin microparticle encapsulated sorghum condensed tannins exhibit potential as an anti-hyperglycaemic agent in a small animal model
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Date
Authors
Links, Malory R.
Taylor, J.R.N. (John Reginald Nuttall)
Kruger, Marlena C.
Naidoo, Vinny
Taylor, Janet
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
In vitro analysis has indicated that sorghum condensed tannins (SCT) survived simulated gastric digestion and inhibited digestive amylases when encapsulated in sorghum kafirin protein microparticles (SCT-KEMS). This study investigated SCT-KEMS as a potential anti-hyperglycaemic nutraceutical agent in vivo. Oral starch tolerance tests were performed on healthy rats. SCT-KEMS prevented a blood glucose spike and decreased the maximum blood glucose level by a mean of 11.8% compared to the water control, the same reduction as the acarbose standard. Neither SCT-KEMS nor acarbose elevated serum insulin levels. Further, the rats took the SCT-KEMS willingly,unlike the case with the unencapsulated SCTs. SCT-KEMS are potentially effective nutraceuticals for the management of hyperglycaemia because of the high affinity of SCT for the proline-rich kafirin and kafirin’s slow digestibility, which enables SCT bitterness to be masked and delivered to the small intestine to inhibit carbohydrate hydrolysis, reducing glycaemic response.
Description
Keywords
Encapsulation, Hyperglycaemia, Kafirin, Oral starch tolerance test, Sorghum tannins, Sorghum condensed tannins (SCT), Sorghum kafirin protein microparticles (SCT-KEMS)
Sustainable Development Goals
Citation
Links, MR, Taylor, J, Kruger, MC, Naidoo, V & Taylor, JRN 2016, 'Kafirin microparticle encapsulated sorghum condensed tannins exhibit potential as an anti-hyperglycaemic agent in a small animal model', Journal of Functional Foods, vol. 20, pp. 394-399.