dc.contributor.author |
Links, Malory R.
|
|
dc.contributor.author |
Taylor, J.R.N. (John Reginald Nuttall)
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|
dc.contributor.author |
Kruger, Marlena C.
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|
dc.contributor.author |
Naidoo, Vinny
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|
dc.contributor.author |
Taylor, Janet
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|
dc.date.accessioned |
2016-06-23T06:14:04Z |
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dc.date.issued |
2016-01 |
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dc.description.abstract |
In vitro analysis has indicated that sorghum condensed tannins (SCT) survived simulated gastric digestion and inhibited digestive amylases when encapsulated in sorghum kafirin protein microparticles (SCT-KEMS). This study investigated SCT-KEMS as a potential anti-hyperglycaemic nutraceutical agent in vivo. Oral starch tolerance tests were performed on healthy rats. SCT-KEMS prevented a blood glucose spike and decreased the maximum blood glucose level by a mean of 11.8% compared to the water control, the same reduction as the acarbose standard. Neither SCT-KEMS nor acarbose elevated serum insulin levels. Further, the rats took the SCT-KEMS willingly,unlike the case with the unencapsulated SCTs. SCT-KEMS are potentially effective nutraceuticals for the management of hyperglycaemia because of the high affinity of SCT for the proline-rich kafirin and kafirin’s slow digestibility, which enables SCT bitterness to be masked and delivered to the small intestine to inhibit carbohydrate hydrolysis, reducing glycaemic response. |
en_ZA |
dc.description.department |
Food Science |
en_ZA |
dc.description.department |
Veterinary Tropical Diseases |
en_ZA |
dc.description.embargo |
2017-01-31 |
|
dc.description.librarian |
hb2016 |
en_ZA |
dc.description.sponsorship |
The SA NRF for Scholarship (84886) and University of Pretoria for a bursary for M.R. Links, The SA THRIP programme for research funding. |
en_ZA |
dc.description.uri |
http://www.elsevier.com/locate/jff |
en_ZA |
dc.identifier.citation |
Links, MR, Taylor, J, Kruger, MC, Naidoo, V & Taylor, JRN 2016, 'Kafirin microparticle encapsulated sorghum condensed tannins exhibit potential as an anti-hyperglycaemic agent in a small animal model', Journal of Functional Foods, vol. 20, pp. 394-399. |
en_ZA |
dc.identifier.issn |
1756-4646 |
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dc.identifier.other |
10.1016/j.jff.2015.11.015 |
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dc.identifier.uri |
http://hdl.handle.net/2263/53366 |
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dc.language.iso |
en |
en_ZA |
dc.publisher |
Elsevier |
en_ZA |
dc.rights |
© 2015 Elsevier Ltd. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Journal of Functional Foods. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Functional Foods, vol. 20, pp. 394-399, 2016. doi : 10.1016/j.jff.2015.11.015. |
en_ZA |
dc.subject |
Encapsulation |
en_ZA |
dc.subject |
Hyperglycaemia |
en_ZA |
dc.subject |
Kafirin |
en_ZA |
dc.subject |
Oral starch tolerance test |
en_ZA |
dc.subject |
Sorghum tannins |
en_ZA |
dc.subject |
Sorghum condensed tannins (SCT) |
en_ZA |
dc.subject |
Sorghum kafirin protein microparticles (SCT-KEMS) |
en_ZA |
dc.title |
Kafirin microparticle encapsulated sorghum condensed tannins exhibit potential as an anti-hyperglycaemic agent in a small animal model |
en_ZA |
dc.type |
Postprint Article |
en_ZA |