Amygdala kisspeptin neurons : putative mediators of olfactory control of the gonadotropic axis

Show simple item record Pineda, Rafael Plaisier, Fabrice Millar, Robert P. Ludwig, Mike 2016-06-22T05:48:38Z 2016-06-22T05:48:38Z 2017
dc.description.abstract Kisspeptins and their receptors are potent regulators of the gonadotropic axis. Kisspeptin neurons are found mainly in the hypothalamic arcuate nucleus and the anteroventral periventricular nucleus. However, there is also a third population of kisspeptin neurons located in the amygdala. We used fluorescence immunohistochemistry to quantify and localize the amygdala kisspeptin neurons and to reveal close apposition and putative innervations by vasopressinergic and tyrosine hydroxylase positive dopaminergic neurons. Using microinjections of retro- and anterograde tracers, and viral transfection systems in rats and transgenic mice, we showed reciprocal connectivity between the accessory olfactory bulb and the amygdala kisspeptin neurons. In vitro recordings indicate an inhibitory action of kisspeptin on mitral cells in the accessory olfactory bulb. Using viral specific-cell gene expression in transgenic mice in combination with double immunofluorescence histochemistry we found that the amygdala kisspeptin neurons also project to gonadotropin-releasing hormone (GnRH) neurons in the preoptic area. Our neuroanatomical and electrophysiological data suggest that amygdala kisspeptin neurons integrate social behaviour and odour information to GnRH neurons in the preoptic area to coordinate the gonadotropic axis and the appropriate output behaviour to odour cues. en_ZA
dc.description.department Mammal Research Institute en_ZA
dc.description.department Zoology and Entomology en_ZA
dc.description.librarian hb2016 en_ZA
dc.description.sponsorship A MRC grant (ML), the Newton International Fellowship program (RP - Ref. NF130516), the Royal Society and the British Academy and by the British Society for Neuroendocrinology (Project Support Grant). en_ZA
dc.description.uri en_ZA
dc.identifier.citation Pineda, R, Plaisier, F, Millar, RP & Ludwig, M 2017, 'Amygdala kisspeptin neurons : putative mediators of olfactory control of the gonadotropic axis', Neuroendocrinology, vol. 104, no. 3, pp. 223-238. en_ZA
dc.identifier.issn 0028-3835 (print)
dc.identifier.issn 1423-0194 (online)
dc.identifier.other 10.1159/000445895
dc.language.iso en en_ZA
dc.publisher Karger en_ZA
dc.rights © 2016 S. Karger AG, Basel en_ZA
dc.subject Amygdala kisspeptin neurons en_ZA
dc.subject Putative mediators en_ZA
dc.subject Kisspeptins en_ZA
dc.subject Gonadotropic axis en_ZA
dc.title Amygdala kisspeptin neurons : putative mediators of olfactory control of the gonadotropic axis en_ZA
dc.type Postprint Article en_ZA

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