Normal flora and bacterial vaginosis in pregnancy : an overview

Show simple item record Redelinghuys, Mathys J. Ehlers, M.M. (Marthie Magdaleen) Dreyer, Andries W. Kock, Martha Magdalena 2016-06-22T05:12:41Z 2016-05
dc.description.abstract The female genital tract is an intricate, yet balanced ecosystem that hosts a variety of different residential microflora. The physiological changes that occur during pregnancy may disrupt this balanced ecosystem and predispose women to a potentially pathogenic microbiota. Bacteria that are associated with bacterial vaginosis (BV) are opportunistic pathogens that frequently form part of this microbiota. The overgrowth of and infections with these bacteria are linked to poor obstetric outcomes and increased transmission of other reproductive tract infections (RTIs). These infections increase women’s susceptibility of acquiring HIV, the rates of HIV shedding and the development of Acquired Immune Deficiency Syndrome (AIDS) in HIV infected patients. It is unknown how the plethora of bacterial species associated with BV contributes to the dynamics of this condition. The use of high-throughput methods have led to the in-depth investigation of different BV-related bacterial species and the functional capabilities of these species. However, the pathogenesis of BV is still poorly defined and the role of individual BV-related bacterial species in specific pregnancy complications is unclear and controversial. The majority of BV infections are asymptomatic and successful diagnosis is complicated by the lack of reliable and standardized diagnostic tests. en_ZA
dc.description.department Medical Microbiology en_ZA
dc.description.embargo 2017-05-31
dc.description.librarian hb2016 en_ZA
dc.description.sponsorship University of Pretoria, the Medical Research Council (South Africa) and the National Health Laboratory Service (NHLS). en_ZA
dc.description.uri en_ZA
dc.identifier.citation Redelinghuys, MJ, Ehlers, MM, Dreyer, AW & Kock, MM 2016, 'Normal flora and bacterial vaginosis in pregnancy : an overview', Critical Reviews in Microbiology, vol. 42, no. 3, pp. 352-363 en_ZA
dc.identifier.issn 1040-841X (print)
dc.identifier.issn 1549-7828 (online)
dc.identifier.other 10.3109/1040841X.2014.954522
dc.language.iso en en_ZA
dc.publisher Taylor and Francis en_ZA
dc.rights © 2016 Taylor & Francis. This is an electronic version of an article published in Critical Reviews in Microbiology, vol. 42, no. 3, pp. 352-363, 2016. doi : 10.3109/1040841X.2014.954522. Critical Reviews in Microbiology is available online at : en_ZA
dc.subject Vaginal microbiota en_ZA
dc.subject Pregnancy en_ZA
dc.subject Microbiology en_ZA
dc.subject Bacterial vaginosis (BV) en_ZA
dc.subject Reproductive tract infections (RTIs) en_ZA
dc.subject Acquired immune deficiency syndrome (AIDS) en_ZA
dc.subject Human immunodeficiency virus (HIV) en_ZA
dc.title Normal flora and bacterial vaginosis in pregnancy : an overview en_ZA
dc.type Postprint Article en_ZA

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