Sapovirus prevalence in children less than five years of age hospitalised for diarrhoeal disease in South Africa, 2009-2013

Show simple item record Page, N.A. (Nicola) Groome, Michelle J. Murray, Tanya Y. Nadan, Sandrama Netshikweta, Rembuluwani Keddy, Karen H. Poonsamy, Bhavani Moyes, Jocelyn Walaza, Sibongile Kahn, Kathleen Kuonza, Lazarus R. Taylor, Maureen B. Madhi, Shabir A. Cohen, Cheryl 2016-06-21T05:43:11Z 2016-05
dc.description.abstract BACKGROUND : Although sapovirus (SaV) has been detected in 2.2–12.7% of gastroenteritis cases globally,there are limited data on SaV epidemiology. OBJECTIVES : Describe the epidemiology, clinical characteristics and factors associated with SaV gastroen-teritis in hospitalised children <5 years of age in South Africa.Study design: Between 2009 and 2013 during prospective diarrhoeal surveillance, stool specimens werecollected from four sites and screened for SaVs and associated enteric pathogens using ELISA, microscopy,conventional and real-time PCR. Epidemiological and clinical data were compared in patients withor without SaV. Odds ratios were assessed by bivariate and stepwise multivariable logistic regressionanalysis. RESULTS : Sapoviruses were detected in 7.7% (238/3103) of children admitted to hospital and 11.4% (9/79)of deaths. Sapovirus was detected more commonly in children 19–24 months compared to <6 months(aOR = 2.3; p = 0.018) and in males (aOR = 2.0; p = 0.001). Additional factors associated with SaV detectionincluded residing with ≥ 7 inhabitants compared to ≤3 (aOR = 2.2; p = 0.011) and concomitant norovirusinfections (aOR = 3.0; p = 0.003). HIV-infected children with SaV were more likely to have bloody stools(aOR = 16.8; p < 0.001), low birth weight (<2.5 kg; aOR = 5.8; p = 0.007) and live in environments withoutflush toilets (aOR = 8.1; p = 0.003) compared to HIV-uninfected children. CONCLUSIONS : Sapoviruses, which are perceived to cause mild diarrhoea, were detected in hospitalisedchildren and diarrhoeal deaths in South Africa. Determinants increasing the odds of SaV included over-crowding and concomitant infections while HIV-infected children with SaV displayed bloody stools, lowbirth weight and reduced access to proper sanitation. Mitigation strategies against SaV infections includeimproved sanitation. en_ZA
dc.description.department Medical Virology en_ZA
dc.description.department School of Health Systems and Public Health (SHSPH) en_ZA
dc.description.embargo 2017-05-31
dc.description.librarian hb2016 en_ZA
dc.description.sponsorship GlaxoSmithKline. en_ZA
dc.description.uri en_ZA
dc.identifier.citation Page, N, Groome, MJ, Murray, TY, Nadan, S, Netshikweta, R, Keddy, KH, Poonsamy, B, Moyes, J, Walaza, S, Kahn, K, Kuonza, L, Taylor, MB, Madhi, SA & Cohen, C 2016, 'Sapovirus prevalence in children less than five years of age hospitalised for diarrhoeal disease in South Africa, 2009-2013', Journal of Clinical Virology, vol. 78, pp. 82-88. en_ZA
dc.identifier.issn 1386-6532 (print)
dc.identifier.issn 1873-5967 (online)
dc.identifier.other 10.1016/j.jcv.2016.03.013
dc.language.iso en en_ZA
dc.publisher Elsevier en_ZA
dc.rights © 2016 Elsevier B.V. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Journal of Clinical Virology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Clinical Virology, vol. 78, pp. 82-88, 2016. doi :10.1016/j.jcv.2016.03.013. en_ZA
dc.subject Caliciviruses en_ZA
dc.subject Children <5 years en_ZA
dc.subject Viral gastroenteritis en_ZA
dc.subject Hospitalised en_ZA
dc.subject South Africa (SA) en_ZA
dc.subject Sapoviruses (SaVs) en_ZA
dc.title Sapovirus prevalence in children less than five years of age hospitalised for diarrhoeal disease in South Africa, 2009-2013 en_ZA
dc.type Postprint Article en_ZA

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