Survival of smear-positive multidrug resistant tuberculosis patients in Witbank, South Africa : a retrospective cohort study

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dc.contributor.author Olaleye, Abiola O.
dc.contributor.author Beke, Andy
dc.date.accessioned 2016-05-31T07:27:01Z
dc.date.issued 2016-06
dc.description.abstract BACKGROUND : A retrospective cohort study was carried out to compare the survival between smear-positive patients and smear-negative multidrug resistant tuberculosis (MDR-TB) patients hospitalised in a specialised TB hospital in Witbank, South Africa. METHODS : A review of medical records of MDR-TB patients treated from 2001 to 2010 was carried out. Survival time was measured from a patient's date of hospitalisation to the date when the patient died, was last treated at the hospital or the end of the study (whichever came first). All patients who were alive until the end of the study period or lost to follow-up were censored and those who died were considered as failures. Survival patterns were estimated using Kaplan Meier plots, log rank tests and life tables. Cox proportional hazards regression analyses were also conducted. RESULTS : The mean age of the 442 MDR-TB patients in the study was 37.7 ± 11.2 years. The incidence rates of mortality were 13.4 and 43.9 per 1000 person-months for smear-negative and smear-positive MDR-TB patients, respectively. Cox proportional hazard regression showed that the predictors of death among MDR-TB patients include HIV co-infection (adjusted Hazard Rate, aHR = 1.89, 95% CI = 1.02-3.52), old age (above 60 years) (aHR = 2.05, 95% CI = 1.04-3.60) and smear positivity at diagnosis (aHR = 3.29, 95% CI = 2.39-4.64). CONCLUSION : The study showed that the probability of survival during the treatment is reduced in MDR-TB patients, who are smear-positive, HIV positive or older than 60 years. Special care should be given to these patients to improve survival. en_ZA
dc.description.department School of Health Systems and Public Health (SHSPH) en_ZA
dc.description.embargo 2017-06-30
dc.description.librarian hb2016 en_ZA
dc.description.uri http://www.tandfonline.com/loi/infd20 en_ZA
dc.identifier.citation Olaleye, AO & Beke, AK 2016, 'Survival of smear-positive multidrug resistant tuberculosis patients in Witbank, South Africa : a retrospective cohort study', Infectious Diseases, vol. 48, no. 6, pp. 422-427. en_ZA
dc.identifier.issn 2374-4235 (print)
dc.identifier.issn 2374-4243 (online
dc.identifier.other 10.3109/23744235.2016.1153806
dc.identifier.uri http://hdl.handle.net/2263/52804
dc.language.iso en en_ZA
dc.publisher Taylor and Francis en_ZA
dc.rights © 2016 Taylor and Francis. This is an electronic version of an article published in Infectious Diseases, vol. 48, no. 6, pp. 422-427, 2016. doi : 10.3109/23744235.2016.1153806. Infectious Diseases is available online at : http://www.tandfonline.com/loi/infd20. en_ZA
dc.subject Multidrug en_ZA
dc.subject Cohort en_ZA
dc.subject Positive en_ZA
dc.subject Resistant en_ZA
dc.subject Smear en_ZA
dc.subject Survival en_ZA
dc.subject Tuberculosis (TB) en_ZA
dc.subject Multidrug resistant tuberculosis (MDR-TB) en_ZA
dc.title Survival of smear-positive multidrug resistant tuberculosis patients in Witbank, South Africa : a retrospective cohort study en_ZA
dc.type Postprint Article en_ZA


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