A non-specific biomarker of disease activity in HIV/AIDS patients from resource-limited environments

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dc.contributor.author Bipath, Priyesh
dc.contributor.author Levay, Peter F.
dc.contributor.author Olorunju, Steve
dc.contributor.author Viljoen, Margaretha
dc.date.accessioned 2016-05-19T06:45:46Z
dc.date.available 2016-05-19T06:45:46Z
dc.date.issued 2015-06
dc.description.abstract BACKGROUND : A general non-specific marker of disease activity that could alert the clinician and prompt further investigation would be of value in patients with HIV/AIDS, especially in resource limited environments. OBJECTIVE : To investigate the potential of neopterin as non-specific biomarker in patients with advanced HIV/AIDS. METHODS : Cross-sectional study in 105 HIV positive patients (75 on highly active antiretroviral treatment (HAART). Neopterin was assessed by enzyme linked immune-absorbent assay and cytokines by flow cytometry. RESULTS : Neopterin levels were significantly higher (p<0.001) for the total patient than for the control group. Significant correlations between neopterin and plasma indicators of inflammation showed neopterin to be a good indicator of active inflammatory status and of the effect of HAART on the immune system. Neopterin was superior to C-reactive protein and to individual cytokines as indicator of immune deficiency. Increased neopterin levels were associated with a decline in albumin, haemoglobin and the albumin/globulin ratio, and with increases in red cell distribution width. CONCLUSIONS : Plasma neopterin is a good non-specific biomarker of disease activity in HIV/AIDS patients. It is a good indicator of inflammatory activity, perpetuation of inflammation-associated co-morbidities, degree of immune deficiency and has predictive value for underlying disease, and for monitoring the HAART response. en_ZA
dc.description.department Internal Medicine en_ZA
dc.description.department Physiology en_ZA
dc.description.department Psychiatry en_ZA
dc.description.librarian am2016 en_ZA
dc.description.sponsorship The Medical Research Council of South African and the South African Sugar Association. en_ZA
dc.description.uri http://www.bioline.org.br/hs en_ZA
dc.identifier.citation Bipath, P, Levay, P, Olorunju, S & Viljoen, M 2015, 'A non-specific biomarker of disease activity in HIV/AIDS patients from resource-limited environments', African Health Sciences, vol. 15, no. 2, pp. 334-343. en_ZA
dc.identifier.issn 1680-6905 (print)
dc.identifier.issn 1729-0503 (online)
dc.identifier.other 10.4314/ahs.v15i2.5
dc.identifier.uri http://hdl.handle.net/2263/52711
dc.language.iso en en_ZA
dc.publisher Makerere University Medical School en_ZA
dc.rights Makerere University Medical School en_ZA
dc.subject Neopterin en_ZA
dc.subject Biomarkers en_ZA
dc.subject Immune activation en_ZA
dc.subject Human immunodeficiency virus (HIV) en_ZA
dc.subject Acquired immune deficiency syndrome (AIDS) en_ZA
dc.title A non-specific biomarker of disease activity in HIV/AIDS patients from resource-limited environments en_ZA
dc.type Article en_ZA


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