Isolation of a novel fusogenic orthoreovirus from Eucampsipoda africana bat flies in South Africa

Show simple item record Jansen van Vuren, Petrus Wiley, Michael Palacios, Gustavo Storm, Nadia McCulloch, Stewart D. Markotter, Wanda Birkhead, Monica Kemp, Alan Paweska, Janusz Tadeusz 2016-05-18T05:52:30Z 2016-05-18T05:52:30Z 2016-02-29
dc.description.abstract We report on the isolation of a novel fusogenic orthoreovirus from bat flies (Eucampsipoda africana) associated with Egyptian fruit bats (Rousettus aegyptiacus) collected in South Africa. Complete sequences of the ten dsRNA genome segments of the virus, tentatively named Mahlapitsi virus (MAHLV), were determined. Phylogenetic analysis places this virus into a distinct clade with Baboon orthoreovirus, Bush viper reovirus and the bat-associated Broome virus. All genome segments of MAHLV contain a 5' terminal sequence (5'-GGUCA) that is unique to all currently described viruses of the genus. The smallest genome segment is bicistronic encoding for a 14 kDa protein similar to p14 membrane fusion protein of Bush viper reovirus and an 18 kDa protein similar to p16 non-structural protein of Baboon orthoreovirus. This is the first report on isolation of an orthoreovirus from an arthropod host associated with bats, and phylogenetic and sequence data suggests that MAHLV constitutes a new species within the Orthoreovirus genus. en_ZA
dc.description.department Microbiology and Plant Pathology en_ZA
dc.description.librarian am2016 en_ZA
dc.description.sponsorship The project is jointly funded by the following grants awarded to: Janusz T. Paweska (CDC Global Disease Detection program, GDD 5U19 GH000571-05/96667), Wanda Markotter (South African National Research Foundation, Grant UID 91496 and 92524; Poliomyelitis Research Foundation, PRF Grant number 12/14) and Petrus Jansen van Vuren (South African National Research Foundation, Incentive Funding for Rated Researchers, Grant UID 85544). en_ZA
dc.description.uri en_ZA
dc.identifier.citation Jansen van Vuren, P, Wiley, M, Palacios, G, Storm, N, McCulloch, S, Markotter, W, Birkhead, M, Kemp, A & Paweska, JT 2016, 'Isolation of a novel fusogenic orthoreovirus from Eucampsipoda africana bat flies in South Africa', Viruses, vol. 8, no. 3, art. #65, pp. 1-25. en_ZA
dc.identifier.issn 1999-4915
dc.identifier.other 10.3390/v8030065
dc.language.iso en en_ZA
dc.publisher MDPI Publishing en_ZA
dc.rights © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license ( en_ZA
dc.subject Fusogenic orthoreovirus en_ZA
dc.subject Reoviridae en_ZA
dc.subject Nycteribiidae en_ZA
dc.subject Bat flies (Eucampsipoda africana) en_ZA
dc.subject Egyptian fruit bats (Rousettus aegyptiacus) en_ZA
dc.subject South Africa (SA) en_ZA
dc.subject Mahlapitsi virus (MAHLV) en_ZA
dc.title Isolation of a novel fusogenic orthoreovirus from Eucampsipoda africana bat flies in South Africa en_ZA
dc.type Article en_ZA

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