Neutrophil extracellular traps and their role in health and disease

Show simple item record Nel, Jan Gert Theron, Annette J. Pool, Roger Durandt, Chrisna Tintinger, Gregory Ronald Anderson, Ronald 2016-05-11T10:57:52Z 2016-05-11T10:57:52Z 2016-01
dc.description.abstract The human innate immune system is indispensable for protection against potentially invasive microbial and viral pathogens, either neutralising them or containing their spread until effective mobilisation of the slower, adaptive (specific), immune response. Until fairly recently, it was believed that the human innate immune system possessed minimal discriminatory activity in the setting of a rather limited range of microbicidal or virucidal mechanisms. However, recent discoveries have revealed that the innate immune system possesses an array of novel pathogen recognition mechanisms, as well as a resourceful and effective alternative mechanism of phagocyte (predominantly neutrophil)-mediated, anti-infective activity known as NETosis. The process of NETosis involves an unusual type of programmed, purposeful cell death, resulting in the extracellular release of a web of chromatin heavily impregnated with antimicrobial proteins. These structures, known as neutrophil extracellular traps (NETs), immobilise and contribute to the eradication of microbial pathogens, ensuring that the anti-infective potential of neutrophils is sustained beyond the lifespan of these cells. The current review is focused on the mechanisms of NETosis and the role of this process in host defence. Other topics reviewed include the potential threats to human health posed by poorly controlled, excessive formation of NETs, specifically in relation to development of autoimmune and cardiovascular diseases, as well as exacerbation of acute and chronic inflammatory disorders of the airways. en_ZA
dc.description.department Haematology en_ZA
dc.description.department Immunology en_ZA
dc.description.department Internal Medicine en_ZA
dc.description.librarian am2016 en_ZA
dc.description.uri en_ZA
dc.identifier.citation Nel JG, Theron AJ, Pool R, Durandt C, Tintinger GR, Anderson R. Neutrophil extracellular traps and their role in health and disease. S Afr J Sci. 2016;112(1/2), Art. #2015-0072, 9 pages. sajs.2016/20150072, en_ZA
dc.identifier.issn 0038-2353 (print)
dc.identifier.issn 1996-7489 (online)
dc.identifier.other 10.17159/
dc.language.iso en en_ZA
dc.publisher AOSIS OpenJournals en_ZA
dc.rights © 2016. The Author(s). Published under a Creative Commons Attribution Licence. en_ZA
dc.subject Antimicrobial activity en_ZA
dc.subject Autoimmune disease en_ZA
dc.subject Innate immunity en_ZA
dc.subject Phagocytes en_ZA
dc.subject Reactive oxygen species en_ZA
dc.title Neutrophil extracellular traps and their role in health and disease en_ZA
dc.type Article en_ZA

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