Progresses towards safe and efficient gene therapy vectors

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Authors

Chira, Sergiu
Jackson, Carlo Stephan
Oprea, Iulian
Ozturk, Ferhat
Pepper, Michael Sean
Diaconu, Iulia
Braicu, Cornelia
Raduly, Lajos-Zsolt
Calin, George A.
Berindan-Neagoe, Ioana

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Impact Journals

Abstract

The emergence of genetic engineering at the beginning of the 1970′s opened the era of biomedical technologies, which aims to improve human health using genetic manipulation techniques in a clinical context. Gene therapy represents an innovating and appealing strategy for treatment of human diseases, which utilizes vehicles or vectors for delivering therapeutic genes into the patients’ body. However, a few past unsuccessful events that negatively marked the beginning of gene therapy resulted in the need for further studies regarding the design and biology of gene therapy vectors, so that this innovating treatment approach can successfully move from bench to bedside. In this paper, we review the major gene delivery vectors and recent improvements made in their design meant to overcome the issues that commonly arise with the use of gene therapy vectors. At the end of the manuscript, we summarized the main advantages and disadvantages of common gene therapy vectors and we discuss possible future directions for potential therapeutic vectors.

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Keywords

Biomedical technologies, Gene therapy, Human diseases, Patients’ body

Sustainable Development Goals

Citation

Chira, S, Jackson, CS, Oprea, I, Ozturk, F, Pepper, MS, Diaconu, I, Braicu, C, Raduly, L-Z, Calin, GA & Berindan-Neagoe, I 2015, 'Progresses towards safe and efficient gene therapy vectors', Oncotarget, vol. 6, no. 321, pp. 30675-30703.