Reliable and cost-effective serodiagnosis of rheumatoid arthritis

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dc.contributor.author Meyer, P.W.A. (Pieter Willem Adriaan)
dc.contributor.author Ally, Mahmood Moosa Tar Mahomed
dc.contributor.author Anderson, Ronald
dc.date.accessioned 2016-04-25T10:46:07Z
dc.date.issued 2016-06
dc.description.abstract Early diagnosis of patients with rheumatoid arthritis (RA) optimises therapeutic benefit and the probability of achieving disease remission. Notwithstanding clinical acumen, early diagnosis is dependent on access to reliable serodiagnostic procedures, as well as on the discerning application and interpretation of these. In the case of RA, however, no disease-specific serodiagnostic procedure is available due to the multi-factorial and polygenic nature of this autoimmune disorder. This has resulted in the development of an array of serodiagnostic procedures based on the detection of autoantibodies reactive with various putative autoantigens. Other procedures based on measurement of elevations in the concentrations of systemic biomarkers of inflammation, most commonly acute phase reactants and cytokines/chemokines, are used as objective indices of disease activity. Following a brief overview of RA research in African populations, the current review is focused on those autoantibodies/biomarkers, specifically rheumatoid factor, anti-citrullinated peptide antibodies and C-reactive protein, which are currently recognised as being the most reliable and cost-effective with respect to disease prediction and diagnosis, as well as in monitoring activity and outcome. en_ZA
dc.description.department Immunology en_ZA
dc.description.department Internal Medicine en_ZA
dc.description.embargo 2017-06-28
dc.description.librarian hb2016 en_ZA
dc.description.uri http://link.springer.com/journal/296 en_ZA
dc.identifier.citation Meyer, PWA, Ally, MMTM & Anderson, R 2016, 'Reliable and cost-effective serodiagnosis of rheumatoid arthritis', Rheumatology International, vol. 36, no. 6, pp. 751-758. en_ZA
dc.identifier.issn 0172-8172 (print)
dc.identifier.issn 1437-160X (online)
dc.identifier.other 10.1007/s00296-016-3433-3
dc.identifier.uri http://hdl.handle.net/2263/52148
dc.language.iso en en_ZA
dc.publisher Springer en_ZA
dc.rights © Springer-Verlag Berlin Heidelberg 2016. The original publication is available at : http://link.springer.comjournal/296. en_ZA
dc.subject Anti-citrullinated peptide antibodies en_ZA
dc.subject Autoantibodies en_ZA
dc.subject C-reactive protein en_ZA
dc.subject Inflammatory biomarkers en_ZA
dc.subject Rheumatoid factor en_ZA
dc.subject Rheumatoid arthritis (RA) en_ZA
dc.title Reliable and cost-effective serodiagnosis of rheumatoid arthritis en_ZA
dc.type Postprint Article en_ZA


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