EBV-positive mucocutaneous ulcer of the oral cavity associated with HIV/AIDS

Show simple item record

dc.contributor.author Bunn, B.K. (Belinda Kathleen)
dc.contributor.author Van Heerden, W.F.P. (Willem Francois Petrus)
dc.date.accessioned 2016-04-21T06:19:25Z
dc.date.available 2016-04-21T06:19:25Z
dc.date.issued 2015-03
dc.description.abstract OBJECTIVE : To present two cases of Epstein-Barr virus (EBV)-positive mucocutaneous ulcer of the oral mucosa in association with human immunodeficiency virus infection. STUDY DESIGN : Two recently diagnosed cases of EBV-positive mucocutaneous ulcer of the oral mucosa in HIV-positive patients were reviewed with regards to their clinical, histomorphological and immunophenotypic features. RESULTS : Both cases presented clinically as well circumscribed ulcers which were histomorphologically characterized by dense superficial polymorphous inflammatory infiltrates. The infiltrates comprised cells with a predominant B-cell phenotype which ranged in size from small to intermediate with occasional large immunoblastic forms. Some of the larger B-cells had a Reed-Sternberg-like morphology. The B-cells were positive for CD20 and co-expressed CD30 and to a lesser extent CD15. EBER positivity was detected in most of the B-cells. CONCLUSION : EBV-positive mucocutaneous ulcer represents an unusual form of lymphoproliferative disorder associated with immune suppression. It should be distinguished from other forms of HIV-associated oral ulceration. en_ZA
dc.description.department Oral Pathology and Oral Biology en_ZA
dc.description.librarian hb2016 en_ZA
dc.description.uri http://www.journals.elsevier.com/oral-surgery-oral-medicine-oral-pathology-and-oral-radiology en_ZA
dc.identifier.citation Bunn, BK & Van Heerden, WFP 2015, 'EBV-positive mucocutaneous ulcer of the oral cavity associated with HIV/AIDS', Oral Surgery Oral Medicine Oral Pathology Oral Radiology, vol. 120, no. 6, pp. 725-732. en_ZA
dc.identifier.issn 2212-4403 (print)
dc.identifier.issn 2212-4411 (online)
dc.identifier.other 10.1016/j.oooo.2015.06.028
dc.identifier.uri http://hdl.handle.net/2263/52084
dc.language.iso en en_ZA
dc.publisher Elsevier en_ZA
dc.rights © 2015 Elsevier Inc. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol. 120, no. 6. pp. 725-732, 2015. doi : 10.1016/j.oooo.2015.06.028. en_ZA
dc.subject EBV-positive en_ZA
dc.subject Mucocutaneous ulcer en_ZA
dc.subject Oral cavity en_ZA
dc.subject Associated with HIV/AIDS en_ZA
dc.subject Epstein-Barr virus (EBV) en_ZA
dc.subject Human immunodeficiency virus (HIV) en_ZA
dc.subject Acquired immune deficiency syndrome (AIDS) en_ZA
dc.title EBV-positive mucocutaneous ulcer of the oral cavity associated with HIV/AIDS en_ZA
dc.type Postprint Article en_ZA


Files in this item

This item appears in the following Collection(s)

Show simple item record