EBV-positive mucocutaneous ulcer of the oral cavity associated with HIV/AIDS
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Date
Authors
Bunn, Belinda Kathleen
Van Heerden, Willem Francois Petrus
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
OBJECTIVE : To present two cases of Epstein-Barr virus (EBV)-positive mucocutaneous ulcer
of the oral mucosa in association with human immunodeficiency virus infection.
STUDY DESIGN : Two recently diagnosed cases of EBV-positive mucocutaneous ulcer of the
oral mucosa in HIV-positive patients were reviewed with regards to their clinical,
histomorphological and immunophenotypic features.
RESULTS : Both cases presented clinically as well circumscribed ulcers which were
histomorphologically characterized by dense superficial polymorphous inflammatory
infiltrates. The infiltrates comprised cells with a predominant B-cell phenotype which ranged
in size from small to intermediate with occasional large immunoblastic forms. Some of the
larger B-cells had a Reed-Sternberg-like morphology. The B-cells were positive for CD20
and co-expressed CD30 and to a lesser extent CD15. EBER positivity was detected in most
of the B-cells.
CONCLUSION : EBV-positive mucocutaneous ulcer represents an unusual form of
lymphoproliferative disorder associated with immune suppression. It should be distinguished
from other forms of HIV-associated oral ulceration.
Description
Keywords
EBV-positive, Mucocutaneous ulcer, Oral cavity, Associated with HIV/AIDS, Epstein-Barr virus (EBV), Human immunodeficiency virus (HIV), Acquired immune deficiency syndrome (AIDS)
Sustainable Development Goals
Citation
Bunn, BK & Van Heerden, WFP 2015, 'EBV-positive mucocutaneous ulcer of the oral cavity associated with HIV/AIDS', Oral Surgery Oral Medicine Oral Pathology Oral Radiology, vol. 120, no. 6, pp. 725-732.