Lack of Marburg virus transmission from experimentally infected to susceptible in-contact Egyptian fruit bats

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dc.contributor.author Paweska, Janusz Tadeusz
dc.contributor.author Jansen van Vuren, Petrus
dc.contributor.author Fenton, Karla A.
dc.contributor.author Graves, Kerry
dc.contributor.author Grobbelaar, Antoinette A.
dc.contributor.author Moolla, Naazneen
dc.contributor.author Leman, Patricia
dc.contributor.author Weyer, Jacqueline
dc.contributor.author Storm, Nadia
dc.contributor.author McCulloch, Stewart D.
dc.contributor.author Scott, Terence Peter
dc.contributor.author Markotter, Wanda
dc.contributor.author Odendaal, Lieza
dc.contributor.author Clift, Sarah J.
dc.contributor.author Geisbert, Thomas W.
dc.contributor.author Hale, Martin J.
dc.contributor.author Kemp, Alan
dc.date.accessioned 2016-04-19T05:06:57Z
dc.date.available 2016-04-19T05:06:57Z
dc.date.issued 2015
dc.description.abstract Egyptian fruit bats (Rousettus aegyptiacus) were inoculated subcutaneously (n = 22) with Marburg virus (MARV). No deaths, overt signs of morbidity, or gross lesions was identified, but microscopic pathological changes were seen in the liver of infected bats. The virus was detected in 15 different tissues and plasma but only sporadically in mucosal swab samples, urine, and fecal samples. Neither seroconversion nor viremia could be demonstrated in any of the in-contact susceptible bats (n = 14) up to 42 days after exposure to infected bats. In bats rechallenged (n = 4) on day 48 after infection, there was no viremia, and the virus could not be isolated from any of the tissues tested. This study confirmed that infection profiles are consistent with MARV replication in a reservoir host but failed to demonstrate MARV transmission through direct physical contact or indirectly via air. Bats develop strong protective immunity after infection with MARV. en_ZA
dc.description.department Paraclinical Sciences en_ZA
dc.description.librarian am2016 en_ZA
dc.description.sponsorship This work was supported by the National Institute for Communicable Diseases. en_ZA
dc.description.uri http://jid.oxfordjournals.org en_ZA
dc.identifier.citation Paweska, JT, Jansen van Vuren, P, Fenton, KA, Graves, K, Grobbelaar, AA, Moolla, N, Leman, P, Weyer, J, Storm, N, McCulloch, SD, Scott, TP, Markotter, W, Odendaal, L, Clift, SJ, Geisbert, TW, Hale, MJ & Kemp, A 2015, 'Lack of Marburg virus transmission from experimentally infected to susceptible in-contact Egyptian fruit bats', Journal of Infectious Diseases, no. 212, pp. s109-s118. en_ZA
dc.identifier.issn 0022-1899 (print)
dc.identifier.issn 1537-6613 (online)
dc.identifier.other 10.1093/infdis/jiv132
dc.identifier.uri http://hdl.handle.net/2263/52050
dc.language.iso en en_ZA
dc.publisher Oxford University Press en_ZA
dc.rights © 2015 by the Infectious Diseases Society of America. All rights reserved. en_ZA
dc.subject Experimental infection en_ZA
dc.subject Egyptian fruit bat en_ZA
dc.subject Shedding en_ZA
dc.subject Horizontal transmission en_ZA
dc.subject Marburg virus en_ZA
dc.title Lack of Marburg virus transmission from experimentally infected to susceptible in-contact Egyptian fruit bats en_ZA
dc.type Article en_ZA


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