Human leukocyte antigen diversity : a Southern African perspective

Show simple item record Tshabalala, Mqondisi Mellet, Juanita Pepper, Michael Sean 2016-04-18T09:07:48Z 2016-04-18T09:07:48Z 2015
dc.description.abstract Despite the increasingly well-documented evidence of high genetic, ethnic, and linguistic diversity amongst African populations, there is limited data on human leukocyte antigen (HLA) diversity in these populations. HLA is part of the host defensemechanism mediated through antigen presentation to effector cells of the immune system. With the high disease burden in southern Africa, HLA diversity data is increasingly important in the design of population-specific vaccines and the improvement of transplantation therapeutic interventions. This review highlights the paucity of HLA diversity data amongst southern African populations and defines a need for information of this kind.This information will support disease association studies, provide guidance in vaccine design, and improve transplantation outcomes. en_ZA
dc.description.department Immunology en_ZA
dc.description.librarian am2016 en_ZA
dc.description.sponsorship The Medical Research Council of South Africa in terms of MRC’s Flagships Awards Project SAMRCRFA-UFSP-01-2013/STEM CELLS, the Institute for Cellular and Molecular Medicine of the University of Pretoria, and the National Research Foundation of South Africa. en_ZA
dc.description.uri en_ZA
dc.identifier.citation Tshabalala, M, Mellet, J & Pepper, MS 2015, 'Human leukocyte antigen diversity : a Southern African perspective', Journal of Immunology Research, vol. 2015, art. no. 746151, pp. 1-11. en_ZA
dc.identifier.issn 2314-8861 (print)
dc.identifier.issn 2314-7156 (online)
dc.identifier.other 10.1155/2015/746151
dc.language.iso en en_ZA
dc.publisher Hindawi Publishing en_ZA
dc.rights © 2015 Mqondisi Tshabalala et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_ZA
dc.subject African populations en_ZA
dc.subject Immune system en_ZA
dc.subject Southern Africa en_ZA
dc.subject Human leukocyte antigen (HLA) en_ZA
dc.title Human leukocyte antigen diversity : a Southern African perspective en_ZA
dc.type Article en_ZA

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