Browsing Arthur (Articles) by UP Author "Reader, Janette"

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Adapt or die : targeting unique transmission-stage biology for malaria elimination

Van der Watt, Mariette Elizabeth; Reader, Janette; Birkholtz, Lyn-Marie (Frontiers Media S.A., 2022-06-09)

Plasmodium parasites have a complex life cycle that includes development in the human host as well as the Anopheles vector. Successful transmission of the parasite between its host and vector therefore requires the ...
The artemiside-artemisox-artemisone-m1 tetrad : efficacies against blood stage p. falciparum parasites, dmpk properties, and the case for artemiside

Gibhard, Liezl; Coertzen, Dina; Reader, Janette; Van der Watt, Mariette Elizabeth; Birkholtz, Lyn-Marie; Wong, Ho Ning; Batty, Kevin T.; Haynes, Richard K.; Wiesner, Lubbe (MDPI, 2021-12-03)

Because of the need to replace the current clinical artemisinins in artemisinin combination therapies, we are evaluating fitness of amino-artemisinins for this purpose. These include the thiomorpholine derivative artemiside ...
New transmission-selective antimalarial agents through hit-to-lead optimization of 2-([1,1 '-Biphenyl]-4-carboxamido)benzoic acid derivatives

Reader, Janette; Opperman, Daniel; Van der Watt, Mariette Elizabeth; Theron, Anjo; Leshabane, Meta Kgaogelo; Da Rocha, Michelle; Turner, Jonathan; Garrabrant, Kathleen; Pina, Ivett; Mills, Catherine; Woster, Patrick M.; Birkholtz, Lyn-Marie (Wiley, 2022-11)

Malaria elimination requires multipronged approaches, including the application of antimalarial drugs able to block humanto- mosquito transmission of malaria parasites. The transmissible gametocytes of Plasmodium ...

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Browsing Arthur (Articles) by UP Author "Reader, Janette"

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