Spectrum of mitochondrial genomic variation and associated clinical presentation of prostate cancer in South African men

Show simple item record

dc.contributor.author McCrow, John P.
dc.contributor.author Petersen, Desiree C.
dc.contributor.author Louw, Melanie
dc.contributor.author Chan, Eva K. F.
dc.contributor.author Harmeyer, Katherine
dc.contributor.author Vecchiarelli, Stefano
dc.contributor.author Lyons, Ruth J.
dc.contributor.author Bornman, Maria S. (Riana)
dc.contributor.author Hayes, Vanessa M.
dc.date.accessioned 2016-03-15T08:16:21Z
dc.date.available 2016-03-15T08:16:21Z
dc.date.issued 2016-03
dc.description.abstract BACKGROUND : Prostate cancer incidence and mortality rates are significantly increased in African–American men, but limited studies have been performed within Sub–Saharan African populations. As mitochondria control energy metabolism and apoptosis we speculate that somatic mutations within mitochondrial genomes are candidate drivers of aggressive prostate carcinogenesis. METHODS : We used matched blood and prostate tissue samples from 87 South African men (77 with African ancestry) to perform deep sequencing of complete mitochondrial genomes. Clinical presentation was biased toward aggressive disease (Gleason score >7, 64%), and compared with men without prostate cancer either with or without benign prostatic hyperplasia. RESULTS : We identified 144 somatic mtDNA single nucleotide variants (SNVs), of which 80 were observed in 39 men presenting with aggressive disease. Both the number and frequency of somatic mtDNA SNVs were associated with higher pathological stage. CONCLUSIONS : Besides doubling the total number of somatic PCa-associated mitochondrial genome mutations identified to date, we associate mutational load with aggressive prostate cancer status in men of African ancestry. en_ZA
dc.description.librarian hb2015 en_ZA
dc.description.sponsorship NIH R21- CA170081, Australian Prostate Cancer Research Centre NSW, the J. Craig Venter Institute, the Garvan Institute, the Petre Foundation, Australia, the Cancer Association of South Africa (CANSA). en_ZA
dc.description.uri http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-0045 en_ZA
dc.identifier.citation McCrow, JP, Petersen, DC, Louw, M, Chan, EKF, Harmeyer, K, Vecchiarelli, S, Lyons, RJ, Bornman, MSR & Hayes, VM 2016, 'Spectrum of mitochondrial genomic variation and associated clinical presentation of prostate cancer in South African men', Prostate, vol. 76, no. 4, pp. 349-358. en_ZA
dc.identifier.issn 0270-4137 (print)
dc.identifier.issn 1097-0045 (online)
dc.identifier.other 10.1002/pros.23126
dc.identifier.uri http://hdl.handle.net/2263/51840
dc.language.iso en en_ZA
dc.publisher Wiley en_ZA
dc.rights © 2015 The Authors. The Prostate published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License. en_ZA
dc.subject African ancestry en_ZA
dc.subject Mitochondria en_ZA
dc.subject Outcomes en_ZA
dc.subject Prostate cancer en_ZA
dc.subject Variation en_ZA
dc.title Spectrum of mitochondrial genomic variation and associated clinical presentation of prostate cancer in South African men en_ZA
dc.type Article en_ZA


Files in this item

This item appears in the following Collection(s)

Show simple item record