On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases : the central roles of LPS and LPS-induced cell death

Show simple item record

dc.contributor.author Kell, Douglas B.
dc.contributor.author Pretorius, Etheresia
dc.date.accessioned 2016-03-08T06:59:37Z
dc.date.available 2016-03-08T06:59:37Z
dc.date.issued 2015-09-01
dc.description.abstract We have recently highlighted (and added to) the considerable evidence that blood can contain dormant bacteria. By definition, such bacteria may be resuscitated (and thus proliferate). This may occur under conditions that lead to or exacerbate chronic, inflammatory diseases that are normally considered to lack a microbial component. Bacterial cell wall components, such as the endotoxin lipopolysaccharide (LPS) of Gram-negative strains, are well known as potent inflammatory agents, but should normally be cleared. Thus, their continuing production and replenishment from dormant bacterial reservoirs provides an easy explanation for the continuing, low-grade inflammation (and inflammatory cytokine production) that is characteristic of many such diseases. Although experimental conditions and determinants have varied considerably between investigators, we summarise the evidence that in a great many circumstances LPS can play a central role in all of these processes, including in particular cell death processes that permit translocation between the gut, blood and other tissues. Such localised cell death processes might also contribute strongly to the specific diseases of interest. The bacterial requirement for free iron explains the strong co-existence in these diseases of iron dysregulation, LPS production, and inflammation. Overall this analysis provides an integrative picture, with significant predictive power, that is able to link these processes via the centrality of a dormant blood microbiome that can resuscitate and shed cell wall components. en_ZA
dc.description.librarian am2015 en_ZA
dc.description.sponsorship The Biotechnology and Biological Sciences Research Council (grant BB/L025752/1), the National Research Foundation (NRF) of South Africa, the Manchester Centre for Synthetic Biology of Fine and Speciality Chemicals (SYNBIOCHEM) (BBSRC grant BB/M017702/1). en_ZA
dc.description.uri http://www.rsc.org/ibiology en_ZA
dc.identifier.citation Kell, DB & Pretorius, E 2015, 'On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases : the central roles of LPS and LPS-induced cell death', Integrative Biology, vol. 7, no.11, pp. 1339-1377. en_ZA
dc.identifier.issn 1757-9694 (print)
dc.identifier.issn 1757-4877 (online)
dc.identifier.other 10.1039/c5ib00158g
dc.identifier.uri http://hdl.handle.net/2263/51715
dc.language.iso en en_ZA
dc.publisher Royal Society of Chemistry en_ZA
dc.rights © The Royal Society of Chemistry 2015 en_ZA
dc.subject Blood en_ZA
dc.subject Bacteria en_ZA
dc.subject Lipopolysaccharide (LPS) en_ZA
dc.subject Chronic inflammatory diseases en_ZA
dc.title On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases : the central roles of LPS and LPS-induced cell death en_ZA
dc.type Article en_ZA


Files in this item

This item appears in the following Collection(s)

Show simple item record