A cross-sectional study on the relationship of age, gestational age and HIV infection to bacterial vaginosis and genital mycoplasma infection

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dc.contributor.author Redelinghuys, Mathys J.
dc.contributor.author Ehlers, M.M. (Marthie Magdaleen)
dc.contributor.author Dreyer, Andries W.
dc.contributor.author Lombaard, H.A.D.T. (Hennie)
dc.contributor.author Olorunju, Steve A.S.
dc.contributor.author Kock, Martha Magdalena
dc.date.accessioned 2016-02-29T12:52:53Z
dc.date.available 2016-02-29T12:52:53Z
dc.date.issued 2015
dc.description.abstract OBJECTIVES : Pregnant women are especially at risk of developing complications when infected with reproductive tract infections (RTIs). The objective of this study was to determine the prevalence of bacterial vaginosis (BV) and genital mycoplasmas in pregnant women and investigate the associations between BV, genital mycoplasmas, HIV infection, age and gestational age. DESIGN : Cross-sectional study with descriptive and analytical components. SETTING : Antenatal clinic of a tertiary academic hospital in South Africa. PARTICIPANTS : 220 pregnant women older than 18 were included in the study and provided self-collected vaginal swabs. PRIMARY AND SECONDARY OUTCOMES : BV and genital mycoplasma colonisation and/or infection in women of differing age, gestational period and HIV status. RESULTS : The prevalence of BV was 17.7% (39/220) (95% CI 12.9 to 23.4), intermediate vaginal flora (IVF) 15% (33/220) (95% CI 10.56 to 20.42), and the overall prevalence of genital mycoplasmas was 84% (185/220) (95% CI 78.47 to 88.58). BV was significantly associated with HIV infection with an OR of 2.84 (95% CI 1.08 to 7.46 and p value=0.034). However, BV was inversely associated with gestational age with an OR of 0.08 (95% CI 0.01 to 0.42 and p value=0.003) for second trimester pregnancies and an OR of 0.03 (95% CI 0.01 to 0.17 and p value<0.001) for third trimester pregnancies using the first trimester as reference. IVF was significantly associated with HIV infection with an OR of 2.7 (95% CI 1.07 to 6.79 and p value=0.035) but not with age or gestational age. Genital mycoplasmas were not significantly associated with age, gestational age, HIV status, BV flora or IVF. CONCLUSIONS : The high infection rate of genital mycoplasmas and the association of BV with HIV found in this study reiterate the importance of screening for these RTIs in high-risk groups such as pregnant women. en_ZA
dc.description.librarian am2015 en_ZA
dc.description.sponsorship The University of Pretoria and the Medical Research Council (South Africa). en_ZA
dc.description.uri http://bmjopen.bmj.com en_ZA
dc.identifier.citation Redelinghuys MJ, Ehlers MM, Dreyer AW, et al. A cross-sectional study on the relationship of age, gestational age and HIV infection to bacterial vaginosis and genital mycoplasma infection. BMJ Open 2015;5:e008530. DOI: 10.1136/bmjopen-2015-008530. en_ZA
dc.identifier.issn 2044-6055
dc.identifier.other 10.1136/bmjopen-2015-008530
dc.identifier.uri http://hdl.handle.net/2263/51608
dc.language.iso en en_ZA
dc.publisher BMJ Publishing Group en_ZA
dc.rights This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license. en_ZA
dc.subject Infection en_ZA
dc.subject Gestational age en_ZA
dc.subject Human immunodeficiency virus (HIV) en_ZA
dc.subject Reproductive tract infections (RTIs) en_ZA
dc.subject Bacterial vaginosis (BV) en_ZA
dc.subject Genital mycoplasmas en_ZA
dc.subject Pregnant women en_ZA
dc.title A cross-sectional study on the relationship of age, gestational age and HIV infection to bacterial vaginosis and genital mycoplasma infection en_ZA
dc.type Article en_ZA


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