Colistin non-susceptible Pseudomonas aeruginosa ST654 with blaNDM-1 arrives in North America

Show simple item record Mataseje, L.F. Peirano, Gisele Church, Deirdre L. Conly, J. Mulvey, M. Pitout, Johann D.D. 2016-01-11T11:36:37Z 2016-03
dc.description.abstract This study describes 3 different blaNDM-1 genetic platforms in 3 different species obtained from the same patient who was directly transferred to an institution in Calgary, Canada, following a prolonged hospital stay in India. The blaNDM-1 in the Escherichia coli was located on a 176kb IncA/C plasmid contained within an ISCR1 region. The blaNDM-1 in the Providencia rettgeri was located on a 117kb IncT plasmid contained within Tn3000, while the blaNDM-1 in Pseudomonas aeruginosa was located on the chromosome within an ISCR3 region. This report highlights the plasticity of the genetic regions and environments associated with blaNDM-1. To the best of our knowledge, this is the first report of P. aeruginosa with blaNDM-1 identified in North America and the first report of blaOXA-181in P. rettgeri. The P. aeruginosa belonged to the international high risk clone ST654 and was non-susceptible to colistin. This case emphasizes the need for appropriate infection prevention and control measures and vigilant screening for carbapenem resistant Gram negative bacteria in patients with a history of travel to endemic areas, such as the Indian subcontinent. en_ZA
dc.description.embargo 2016-09-30
dc.description.librarian hb2015 en_ZA
dc.description.sponsorship In part by a research grant from the Calgary Laboratory Services (#10009392). en_ZA
dc.description.uri en_ZA
dc.identifier.citation Mataseje, LF, Peirano, G, Church, DL, Conly,J, Mulvey,M & Pitout, JDD 2016, 'Colistin non-susceptible Pseudomonas aeruginosa ST654 with blaNDM-1 arrives in North America', Antimicrobial Agents and Chemotherapy, vol. 60, no. 3, pp. 1794-1800. en_ZA
dc.identifier.issn 0066-4804 (print)
dc.identifier.issn 1098-6596 (online)
dc.language.iso en en_ZA
dc.publisher American Society for Microbiology en_ZA
dc.rights © 2015, American Society for Microbiology. All Rights Reserved. en_ZA
dc.subject blaNDM-1 en_ZA
dc.subject North America en_ZA
dc.subject Pseudomonas aeruginosa ST654 en_ZA
dc.title Colistin non-susceptible Pseudomonas aeruginosa ST654 with blaNDM-1 arrives in North America en_ZA
dc.type Postprint Article en_ZA

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