dc.contributor.author |
Mataseje, L.F.
|
|
dc.contributor.author |
Peirano, Gisele
|
|
dc.contributor.author |
Church, Deirdre L.
|
|
dc.contributor.author |
Conly, J.
|
|
dc.contributor.author |
Mulvey, M.
|
|
dc.contributor.author |
Pitout, Johann D.D.
|
|
dc.date.accessioned |
2016-01-11T11:36:37Z |
|
dc.date.issued |
2016-03 |
|
dc.description.abstract |
This study describes 3 different blaNDM-1 genetic platforms in 3 different species obtained from
the same patient who was directly transferred to an institution in Calgary, Canada, following a
prolonged hospital stay in India. The blaNDM-1 in the Escherichia coli was located on a 176kb
IncA/C plasmid contained within an ISCR1 region. The blaNDM-1 in the Providencia rettgeri was
located on a 117kb IncT plasmid contained within Tn3000, while the blaNDM-1 in Pseudomonas
aeruginosa was located on the chromosome within an ISCR3 region. This report highlights the
plasticity of the genetic regions and environments associated with blaNDM-1. To the best of our
knowledge, this is the first report of P. aeruginosa with blaNDM-1 identified in North America and
the first report of blaOXA-181in P. rettgeri. The P. aeruginosa belonged to the international high
risk clone ST654 and was non-susceptible to colistin. This case emphasizes the need for
appropriate infection prevention and control measures and vigilant screening for carbapenem
resistant Gram negative bacteria in patients with a history of travel to endemic areas, such as the
Indian subcontinent. |
en_ZA |
dc.description.embargo |
2016-09-30 |
|
dc.description.librarian |
hb2015 |
en_ZA |
dc.description.sponsorship |
In part by a research grant from the Calgary Laboratory Services (#10009392). |
en_ZA |
dc.description.uri |
http://aac.asm.org |
en_ZA |
dc.identifier.citation |
Mataseje, LF, Peirano, G, Church, DL, Conly,J, Mulvey,M & Pitout, JDD 2016, 'Colistin non-susceptible Pseudomonas aeruginosa ST654 with blaNDM-1 arrives in North America', Antimicrobial Agents and Chemotherapy, vol. 60, no. 3, pp. 1794-1800. |
en_ZA |
dc.identifier.issn |
0066-4804 (print) |
|
dc.identifier.issn |
1098-6596 (online) |
|
dc.identifier.uri |
http://hdl.handle.net/2263/51190 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
American Society for Microbiology |
en_ZA |
dc.rights |
© 2015, American Society for Microbiology. All Rights Reserved. |
en_ZA |
dc.subject |
blaNDM-1 |
en_ZA |
dc.subject |
North America |
en_ZA |
dc.subject |
Pseudomonas aeruginosa ST654 |
en_ZA |
dc.title |
Colistin non-susceptible Pseudomonas aeruginosa ST654 with blaNDM-1 arrives in North America |
en_ZA |
dc.type |
Postprint Article |
en_ZA |