Ligand binding pocket formed by evolutionarily conserved residues in the glucagon-like peptide-1 (GLP-1) receptor core domain
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| dc.contributor.author | Moon, Mi Jin
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| dc.contributor.author | Lee, Yoo-Na
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| dc.contributor.author | Park, Sumi
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| dc.contributor.author | Reyes-Alcaraz, Arfaxad
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| dc.contributor.author | Hwang, Jong-Ik
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| dc.contributor.author | Millar, Robert P.
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| dc.contributor.author | Choe, Han
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| dc.contributor.author | Seong, Jae Young
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| dc.date.accessioned | 2015-12-14T09:14:34Z | |
| dc.date.issued | 2015-02 | |
| dc.description.abstract | BACKGROUND : Little is known about the interaction between GLP-1 and the heptahelical core domain of GLP1R. RESULTS : GLP-1 Asp9 and Gly4 interact with the evolutionarily conserved residues in extracellular loop 3. CONCLUSION : Ligand binding pocket formed by evolutionarily conserved residues in the GLP1R core domain. Significance: This study highlights the mechanism underlying high affinity interaction between GLP-1 and the binding pocket of the receptor. | en_ZA |
| dc.description.embargo | 2016-02-28 | |
| dc.description.librarian | hb2015 | en_ZA |
| dc.description.uri | http://www.jbc.org | en_ZA |
| dc.identifier.citation | Moon, MJ, Lee, Y-N, Park, S, Reyes-Alcaraz, A, Hwang, J-I, Millar, RP, Choe, H & Seong, JY 2015, 'Ligand binding pocket formed by evolutionarily conserved residues in the glucagon-like peptide-1 (GLP-1) receptor core domain', Journal of Biological Chemistry, vol. 290, no. 9, pp. 5696-5706. | en_ZA |
| dc.identifier.issn | 0021-9258 (print) | |
| dc.identifier.issn | 1083-351X (online) | |
| dc.identifier.other | 10.1074/jbc.M114.612606 | |
| dc.identifier.uri | http://hdl.handle.net/2263/51181 | |
| dc.language.iso | en | en_ZA |
| dc.publisher | American Society for Biochemistry and Molecular Biology | en_ZA |
| dc.rights | © 2015 by The American Society for Biochemistry and Molecular Biology, Inc. This research was originally published in Journal of Biological Chemistry. Moon, MJ, Lee, Y-N, Park, S, Reyes-Alcaraz, A, Hwang, J-I, Millar, RP, Choe, H & Seong, JY, Ligand binding pocket formed by evolutionarily conserved residues in the glucagon-like peptide-1 (GLP-1) receptor core domain, 2015, vol. 290, no. 9, pp. 5696–5706, doi : 10.1074/jbc.M114.612606 . | en_ZA |
| dc.subject | Glucagon-like peptide-1 (GLP-1) | en_ZA |
| dc.subject | Molecular mechanism | en_ZA |
| dc.subject | Interaction | en_ZA |
| dc.subject | Ligand binding pocket | en_ZA |
| dc.title | Ligand binding pocket formed by evolutionarily conserved residues in the glucagon-like peptide-1 (GLP-1) receptor core domain | en_ZA |
| dc.type | Postprint Article | en_ZA |
