Integration of genomic and proteomic analyses in the classification of the Siphoviridae family

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Authors

Adriaenssens, Evelien M.
Edwards, Robert P.
Nash, John H.E.
Mahadevan, Padmanabhan
Seto, Donald
Ackermann, Hans-Wolfgang
Lavigne, Rob
Kropinski, Andrew M.

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Publisher

Elsevier

Abstract

Using a variety of genomic (BLASTN, ClustalW) and proteomic (Phage Proteomic Tree, CoreGenes) tools we have tackled the taxonomic status of members of the largest bacteriophage family, the Siphoviridae. In all over 400 phages were examined and we were able to propose 39 new genera, comprising 216 phage species, and add 62 species to two previously defined genera (Phic3unalikevirus; L5likevirus) grouping, in total, 390 fully sequenced phage isolates. Many of the remainder are orphans which the Bacterial and Archaeal Viruses Subcommittee of the International Committee on Taxonomy of Viruses (ICTV) chooses not to ascribe genus status at the time being.

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Keywords

Siphoviridae, Taxonomy, Phage ProteomicTree, CoreGenes, ClustalW, International Committee on Taxonomy of Viruses (ICTV)

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Citation

Adriaenssens, EM, Edwards, R, Nash, JHE, Mahadevan, P, Seto, D, Ackermann, HW, Lavigne, R & Kropinski, AM 2015, 'Integration of genomic and proteomic analyses in the classification of the Siphoviridae family', Virology, vol. 477, pp. 144-154.