Evaluating the possible role of 68Ga-citrate PET/CT in the characterization of indeterminate lung lesions

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dc.contributor.author Vorster, Mariza
dc.contributor.author Maes, Alex
dc.contributor.author Jacobs, Aldrich
dc.contributor.author Malefahlo, Sidney
dc.contributor.author Pottel, Hans
dc.contributor.author Van de Wiele, Christophe
dc.contributor.author Sathekge, Mike Machaba
dc.date.accessioned 2015-11-09T07:17:10Z
dc.date.available 2015-11-09T07:17:10Z
dc.date.issued 2014-07
dc.description.abstract We sought to determine whether PET/CT imaging with 68Ga-citrate could be of value in distinguishing benign from malignant lung pathology in a setting with a high prevalence of granulomatous diseases. METHODS : Thirty-six consecutive patients with indeterminate lung lesions prospectively underwent dual time point (60 and 120 min) 68Ga-citrate PET/CT study prior to lung biopsy. Qualitative and semi-quantitative measures of tracer uptake in the lung lesions (SUVmax) were compared to the histopathology in order to establish an imaging pattern to distinguish benign from malignant lesions. RESULTS : Fourteen patients (38.9 %) were diagnosed with a malignant lesion, 12 (33.3 %) with tuberculosis (TB), and 10 participants (27.8 %) with other benign lung lesions. At 60-min post-injection, patients who were diagnosed with a malignant lesion (n = 14) demonstrated a mean SUVmax of 3.36 ± 1.14, with a median value of 3.04 (min = 1.56, max = 4.65).Those with TB (n = 12) demonstrated a SUVmax of 3.99 ± 2.28, and a median value of 3.71 (pct25 = 2.19, pct75 = 4.95). In patients with other benign lesions (n = 10), the following values were observed: a SUVmax of 2.70 ± 1.31, a median value of 2.50 (pct25 = 1.76, pct75 = 3.59). The mean values of these three types of pathology were not statistically significant (p = 0.1919), and therefore the SUVmax could not be used to accurately distinguish between these lesions using both early and delayed imaging. CONCLUSION : This study, as the first 68Ga-citrate PET/CT in humans for the in vivo imaging of lung pathology, demonstrated its potential for the detection of both malignancy and TB. However, 68Ga-citrate seemed incapable of providing a clear distinction between malignant and benign lung lesions in a setting with a high prevalence of granulomatous diseases such as TB. en_ZA
dc.description.librarian hb2015 en_ZA
dc.description.uri http://link.springer.com/journal/12149 en_ZA
dc.identifier.citation Vorster, M, Maes, A, Jacobs, A, Malefahlo, S, Pottel, H, Van de Wiele, C & Sathekge, MM 2014, 'Evaluating the possible role of 68Ga-citrate PET/CT in the characterization of indeterminate lung lesions', Annals of Nuclear Medicine, vol. 28, no. 6, pp. 523-530. en_ZA
dc.identifier.issn 0914-7187 (print)
dc.identifier.issn 1864-6433 (online)
dc.identifier.other 10.1007/s12149-014-0842-9
dc.identifier.uri http://hdl.handle.net/2263/50381
dc.language.iso en en_ZA
dc.publisher Springer en_ZA
dc.rights © The Japanese Society of Nuclear Medicine 2014. The original publication is available at : http://link.springer.comjournal/12149. en_ZA
dc.subject 68Ga-citrate en_ZA
dc.subject Lung lesions en_ZA
dc.subject Tuberculosis (TB) en_ZA
dc.subject PET/CT en_ZA
dc.subject Positron emission tomography (PET) en_ZA
dc.subject Computerized tomography (CT) en_ZA
dc.title Evaluating the possible role of 68Ga-citrate PET/CT in the characterization of indeterminate lung lesions en_ZA
dc.type Postprint Article en_ZA


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