Epidemiological and virological characteristics of influenza B : results of the Global Influenza B Study

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dc.contributor.author Caini, Saverio
dc.contributor.author Huang, Q. Sue
dc.contributor.author Ciblak, Meral A.
dc.contributor.author Kusznierz, Gabriela
dc.contributor.author Owen, Rhonda
dc.contributor.author Wangchuk, Sonam
dc.contributor.author Henriques, Cl audio M.P.
dc.contributor.author Njouom, Richard
dc.contributor.author Fasce, Rodrigo A.
dc.contributor.author Yu, Hongjie
dc.contributor.author Feng, Luzhao
dc.contributor.author Zambon, Maria
dc.contributor.author Clara, Alexey W.
dc.contributor.author Kosasih, Herman
dc.contributor.author Puzelli, Simona
dc.contributor.author Kadjo, Herve
dc.contributor.author Emukule, Gideon
dc.contributor.author Heraud, Jean-Michel
dc.contributor.author Wei Ang, Li
dc.contributor.author Venter, Marietjie
dc.contributor.author Mironenko, Alla
dc.contributor.author Brammer, Lynnette
dc.contributor.author Mai, Le Thi Quynh
dc.contributor.author Schellevis, François
dc.contributor.author Plotkin, Stanley
dc.contributor.author Paget, John
dc.date.accessioned 2015-11-04T06:07:29Z
dc.date.available 2015-11-04T06:07:29Z
dc.date.issued 2015
dc.description.abstract INTRODUCTION Literature on influenza focuses on influenza A, despite influenza B having a large public health impact. The Global Influenza B Study aims to collect information on global epidemiology and burden of disease of influenza B since 2000. METHODS Twenty-six countries in the Southern (n = 5) and Northern (n = 7) hemispheres and intertropical belt (n = 14) provided virological and epidemiological data. We calculated the proportion of influenza cases due to type B and Victoria and Yamagata lineages in each country and season; tested the correlation between proportion of influenza B and maximum weekly influenzalike illness (ILI) rate during the same season; determined the frequency of vaccine mismatches; and described the age distribution of cases by virus type. RESULTS The database included 935 673 influenza cases (2000– 2013). Overall median proportion of influenza B was 22 6%, with no statistically significant differences across seasons. During seasons where influenza B was dominant or co-circulated (>20% of total detections), Victoria and Yamagata lineages predominated during 64% and 36% of seasons, respectively, and a vaccine mismatch was observed in 25% of seasons. Proportion of influenza B was inversely correlated with maximum ILI rate in the same season in the Northern and (with borderline significance) Southern hemispheres. Patients infected with influenza B were usually younger (5–17 years) than patients infected with influenza A. CONCLUSION Influenza B is a common disease with some epidemiological differences from influenza A. This should be considered when optimizing control/prevention strategies in different regions and reducing the global burden of disease due to influenza. en_ZA
dc.description.librarian am2015 en_ZA
dc.description.uri http://www.influenzajournal.com en_ZA
dc.identifier.citation Caini, S, Huang, QS, Ciblak, MA, Kusznierz, G, Owen, R et al. 2015, 'Epidemiological and virological characteristics of influenza B: results of the Global Influenza B Study', Influenza and Other Respiratory Viruses, vol. 9, suppl. 1, pp. 3–12. en_ZA
dc.identifier.issn 1750-2640 (print)
dc.identifier.issn 1750-2659 (online)
dc.identifier.other 10.1111/irv.12319
dc.identifier.uri http://hdl.handle.net/2263/50318
dc.language.iso en en_ZA
dc.publisher Wiley en_ZA
dc.rights © 2015 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, en_ZA
dc.subject Burden of disease en_ZA
dc.subject Epidemiology en_ZA
dc.subject Global Influenza B Study (GIBS) en_ZA
dc.subject Influenza en_ZA
dc.subject Vaccination en_ZA
dc.subject Vaccine mismatch en_ZA
dc.title Epidemiological and virological characteristics of influenza B : results of the Global Influenza B Study en_ZA
dc.type Article en_ZA


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