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dc.contributor.author | Nielsen, Vance G. | |
dc.contributor.author | Pretorius, Etheresia | |
dc.date.accessioned | 2015-11-02T05:50:13Z | |
dc.date.available | 2015-11-02T05:50:13Z | |
dc.date.issued | 2014-03 | |
dc.description.abstract | Within the past decade there have been several investigations attempting to define the impact of exogenous and endogenous carbon monoxide exposure on hemostasis. Critically, two bodies of literature have emerged, with carbon monoxide mediated platelet inhibition cited as a cause of in vitro human and in vitro/in vivo rodent anticoagulation. In contrast, interaction with heme groups associated with fibrinogen, α2-antiplasmin and plasmin by carbon monoxide has resulted in enhanced coagulation and decreased fibrinolysis in vitro in human and other species, and in vivo in rabbits. Of interest, the ultrastructure of platelet rich plasma thrombi demonstrates an abnormal increase in fine fiber formation and matting that are obtained fromhumans exposed to carbonmonoxide. Further, thrombi obtained from humans and rabbits have very similar ultrastructures, whereas mice and rats have more fine fibers and matting present. In sum, there may be species specific differences with regard to hemostatic response to carbon monoxide. Carbon monoxide may be a Janus-faced molecule, with potential to attenuate or exacerbate thrombophilic disease. | en_ZA |
dc.description.librarian | hb2015 | en_ZA |
dc.description.uri | http://www.elsevier .com/locate/thromres | en_ZA |
dc.identifier.citation | Nielsen, VG & Pretorius, E 2014, 'Carbon monoxide : anticoagulant or procoagulant?', Thrombosis Research, vol. 133, pp. 315-321. | en_ZA |
dc.identifier.issn | 0049-3848 (print) | |
dc.identifier.issn | 1879-2472 (online) | |
dc.identifier.other | 10.1016/j.thromres.2013.12.004 | |
dc.identifier.uri | http://hdl.handle.net/2263/50289 | |
dc.language.iso | en | en_ZA |
dc.publisher | Elsevier | en_ZA |
dc.rights | © 2013 Elsevier Ltd. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Thrombosis Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Thrombosis Research, vol. 133, pp. 315-321, 2014. doi : 10.1016/j.thromres.2013.12.004. | en_ZA |
dc.subject | Carbon monoxide | en_ZA |
dc.subject | Platelet | en_ZA |
dc.subject | Fibrinogen | en_ZA |
dc.subject | Coagulation | en_ZA |
dc.subject | Fibrinolysis | en_ZA |
dc.title | Carbon monoxide : anticoagulant or procoagulant? | en_ZA |
dc.type | Postprint Article | en_ZA |