Antimicrobial peptides : their role as infection-selective tracers for molecular imaging

Show simple item record Ebenhan, Thomas Gheysens, Olivier Kruger, Hendrik G. Zeevaart, Jan Rijn Sathekge, Mike Machaba 2015-10-20T12:42:02Z 2015-10-20T12:42:02Z 2014-08
dc.description.abstract Antimicrobial peptides (AMPs) are a heterogeneous class of compounds found in a variety of organisms including humans and, so far, hundreds of these structures have been isolated and characterised. They can be described as natural microbicide, selectively cytotoxic to bacteria, whilst showing minimal cytotoxicity towards the mammalian cells of the host organism. They act by their relatively strong electrostatic attraction to the negatively charged bacterial cells and a relatively weak interaction to the eukaryote host cells. The ability of these peptides to accumulate at sites of infection combined with the minimal host’s cytotoxicity motivated for this review to highlight the role and the usefulness of AMPs for PET with emphasis on their mechanism of action and the different interactions with the bacterial cell. These details are key information for their selective properties. We also describe the strategy, design, and utilization of these peptides as potential radiopharmaceuticals as their combination with nuclear medicine modalities such as SPECT or PET would allow noninvasive whole-body examination for detection of occult infection causing, for example, fever of unknown origin. en_ZA
dc.description.librarian hb2015 en_ZA
dc.description.sponsorship National Research Foundation (NRF), the Institute of Cellular and Molecular Medicine and the Nuclear Technologies in Medicine and the Biosciences Initiative (NTeMBI), a national technology platform developed and managed by the South African Nuclear Energy Corporation (Necsa) and funded by the Department of Science and Technology (DST). en_ZA
dc.description.uri en_ZA
dc.identifier.citation Ebenhan, T, Gheysens, O, Kruger, HG, Zeevaart, JR & Sathekge, MM 2014, 'Antimicrobial peptides : their role as infection-selective tracers for molecular imaging', Biomed Research International, vol. 2014, art #867381, pp. 1-15. en_ZA
dc.identifier.issn 2314-6133 (print)
dc.identifier.issn 2314-6141 (online)
dc.identifier.other 10.1155/2014/867381
dc.language.iso en en_ZA
dc.publisher Hindawi Publishing en_ZA
dc.rights © 2014 Thomas Ebenhan et al. This is an open access article distributed under the Creative Commons Attribution License. en_ZA
dc.subject Infection-selective tracers en_ZA
dc.subject Molecular imaging en_ZA
dc.subject Antimicrobial peptide (AMP) en_ZA
dc.title Antimicrobial peptides : their role as infection-selective tracers for molecular imaging en_ZA
dc.type Article en_ZA

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