Selective pinning control of the average disease transmissibility in an HIV contact network

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dc.contributor.author Du Toit, Eben Francois
dc.contributor.author Craig, Ian K.
dc.date.accessioned 2015-08-25T07:46:40Z
dc.date.available 2015-08-25T07:46:40Z
dc.date.issued 2015-07
dc.description.abstract Medication is applied to the HIV-infected nodes of high-risk contact networks with the aim of controlling the spread of disease to a predetermined maximum level. This intervention, known as pinning control, is performed both selectively and randomly in the network. These strategies are applied to 300 independent realizations per reference level of incidence on connected undirectional networks without isolated components and varying in size from 100 to 10 000 nodes per network. It is shown that a selective on-off pinning control strategy can control the networks studied with limited steady-state error and, comparing the medians of the doses from both strategies, uses 51.3% less medication than random pinning of all infected nodes. Selective pinning could possibly be used by public health specialists to identify the maximum level of HIV incidence in a population that can be achieved in a constrained funding environment. en_ZA
dc.description.librarian hb2015 en_ZA
dc.description.sponsorship South African Centre for Epidemiological Modelling and Analysis (SACEMA).In part by the National Research Foundation of South Africa (Grant Number 90533). en_ZA
dc.description.uri http://journals.aps.org en_ZA
dc.identifier.citation Du Toit, EF & Craig, IK 2015, 'Selective pinning control of the average disease transmissibility in an HIV contact network', Physical Review E, vol. 92, no. 1, art. # 012810, pp. 1-8 en_ZA
dc.identifier.issn 1539-3755 (print)
dc.identifier.issn 1550-2376 (online)
dc.identifier.other 10.1103/PhysRevE.92.012810
dc.identifier.uri http://hdl.handle.net/2263/49507
dc.language.iso en en_ZA
dc.publisher American Physical Society en_ZA
dc.rights © 2015 American Physical Society en_ZA
dc.subject HIV contact network en_ZA
dc.subject Selective pinning control en_ZA
dc.subject Average disease en_ZA
dc.subject Predetermined maximum level en_ZA
dc.subject Human immunodeficiency virus (HIV) en_ZA
dc.title Selective pinning control of the average disease transmissibility in an HIV contact network en_ZA
dc.type Postprint Article en_ZA


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