Interplay between ultrastructural findings and atherothrombotic complications in type 2 diabetes mellitus

Show simple item record Soma, Prashilla Pretorius, Etheresia 2015-08-20T05:51:47Z 2015-08-20T05:51:47Z 2015-07
dc.description.abstract Accelerated atherosclerosis is the main underlying factor contributing to the high risk of atherothrombotic events in patients with diabetes mellitus and atherothrombotic complications are the main cause of mortality. Like with many bodily systems, pathology is observed when the normal processes are exaggerated or uncontrolled. This applies to the processes of coagulation and thrombosis as well. In diabetes, in fact, the balance between prothrombotic and fibrinolytic factors is impaired and thus the scale is tipped towards a prothrombotic and hypofibrinolytic milieu, which in association with the vascular changes accompanying plaque formation and ruptures, increases the prevalence of ischaemic events such as angina and myocardial infarction. Apart from traditional, modifiable risk factors for cardiovascular disease like hypertension, smoking, elevated cholesterol; rheological properties, endogenous fibrinolysis and impaired platelet activity are rapidly gaining significance in the pathogenesis of atherosclerosis especially in diabetic subjects. Blood clot formation represents the last step in the athero-thrombotic process, and the structure of the fibrin network has a role in determining predisposition to cardiovascular disease. It is no surprise that just like platelets and fibrin networks, erythrocytes have been shown to play a role in coagulation as well. This is in striking contrast to their traditional physiological role of oxygen transport. In fact, emerging evidence suggests that erythrocytes enhance functional coagulation properties and platelet aggregation. Among the spectrum of haematological abnormalities in diabetes, erythrocyte aggregation and decreased deformability of erythrocytes predominate. More importantly, they are implicated in the pathogenesis of microvascular complications of diabetes. The morphology of platelets, fibrin networks and erythrocytes are thus essential role players in unravelling the pathogenesis of cardiovascular complications in diabetic subjects. en_ZA
dc.description.librarian hb2015 en_ZA
dc.description.sponsorship National Research Foundation of South Africa (UNIQUE GRANT NO: 92709) and the MRC: E Pretorius (fund number A0X331). en_ZA
dc.description.uri en_ZA
dc.identifier.citation Soma, P & Pretorius, E 2015, 'Interplay between ultrastructural findings and atherothrombotic complications in type 2 diabetes mellitus', Cardiovascular Diabetology, vol. 14, no. 96, pp. 1-9. en_ZA
dc.identifier.issn 1475-2840 (online)
dc.identifier.other 10.1186/s12933-015-0261-9
dc.language.iso en en_ZA
dc.publisher BioMed Central en_ZA
dc.rights © 2015 Soma and Pretorius.Licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.orglicenses/by/4.0). en_ZA
dc.subject Diabetes en_ZA
dc.subject Morphology en_ZA
dc.subject Platelets en_ZA
dc.subject Fibrin en_ZA
dc.subject Erythrocytes en_ZA
dc.subject Atherosclerosis en_ZA
dc.title Interplay between ultrastructural findings and atherothrombotic complications in type 2 diabetes mellitus en_ZA
dc.type Article en_ZA

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