The problem of chemotherapy in oesophagostomiasis cannot be solved satisfactorily until a method of dosing sheep into the abomasum has been found. With ordinary dosing useful drugs may be swallowed into the rumen and will then not act. The results obtained with 72 different drugs and various combinations of these, tested on 308 sheep, are tabulated and briefly discussed. The best results were obtained with relatively insoluble drugs, which are most likely to reach the colon and which may apparently be ingested by the parasites. The most promising drugs appear to be arsenious sulphide and sodium fluosilicate, while certain compounds of copper and mercury may be useful.
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