Cyclic neutropenia in a basset hound

Show simple item record Koster, Liza Sally Harper, Cindy Kim Goddard, Amelia 2015-06-15T10:38:06Z 2015-06-15T10:38:06Z 2015
dc.description.abstract A 6 month old, male basset hound was referred for intermittent malaise, and pyrexia that repeated every 10-11 days. Sequential blood counts and bone marrow aspirates demonstrated severe neutropaenia and increased myeloid precursor cells in the bone marrow from day two of each cycle. By day five the bone marrow had predominantly mature neutrophils and band cells, and by day 10 the myeloid precursors had decreased with a myeloid:erythroid of 0.4:1. During the same period the blood neutrophils had rebounded to normal counts by day five, and were declining by day 9 and 10. The monocytes and platelets were oscillating in an opposite phase to the neutrophils. The age of onset, regular cycle length, oscillation of neutrophil, platelet and monocyte counts and characteristic bone marrow cytology were diagnostic for cyclic neutropaenia. This syndrome has never before been described in any breed other than the grey collie. The grey collie gene mutation was not found in this dog. However, based on the clinical signs, and haematological and bone marrow results, it can be deduced that cyclic neutropaenia may develop as a result of other mutations in neutrophil elastase expression. en_ZA
dc.description.librarian hb2015 en_ZA
dc.description.uri en_ZA
dc.identifier.citation Köster, L, Harper, C & Goddard, A 2015, 'Cyclic neutropenia in a basset hound', Veterinary Record Case Reports, vol. 3, no. 1, doi:10.1136/vetreccr-2014-000135 en_ZA
dc.identifier.issn 2052-6121
dc.identifier.other 10.1136/vetreccr-2014-000135
dc.language.iso en en_ZA
dc.publisher BMJ Publishing Group en_ZA
dc.rights © 2015 by the BMJ Publishing Group Ltd. All rights reserved. en_ZA
dc.subject Cyclic neutropaenia en_ZA
dc.subject Basset hound en_ZA
dc.title Cyclic neutropenia in a basset hound en_ZA
dc.type Postprint Article en_ZA

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