Southern African Treatment Resistance Network (SATuRN) RegaDB HIV drug resistance and clinical management database : supporting patient management, surveillance and research in southern Africa

Show simple item record Manasa, Justen Lessells, Richard J. Rossouw, Theresa M. Naidu, Kevindra K. Van Vuuren, Cloete Goedhals, Dominique Van Zyl, Gert Bester, Armand Skingsley, Andrew Stoot, Katharine E. Danaviah, S. Chetty, Terusha Singh, Lavanya Moodley, Pravi Iwuji, Collins McGrath, Nuala Seebregts, Christopher J. De Oliveira, Tulio 2015-06-04T07:17:13Z 2015-06-04T07:17:13Z 2014
dc.description.abstract Substantial amounts of data have been generated from patient management and academic exercises designed to better understand the human immunodeficiency virus (HIV) epidemic and design interventions to control it. A number of specialized databases have been designed to manage huge data sets from HIV cohort, vaccine, host genomic and drug resistance studies. Besides databases from cohort studies, most of the online databases contain limited curated data and are thus sequence repositories. HIV drug resistance has been shown to have a great potential to derail the progress made thus far through antiretroviral therapy. Thus, a lot of resources have been invested in generating drug resistance data for patient management and surveillance purposes. Unfortunately, most of the data currently available relate to subtype B even though >60% of the epidemic is caused by HIV-1 subtype C. A consortium of clinicians, scientists, public health experts and policy markers working in southern Africa came together and formed a network, the Southern African Treatment and Resistance Network (SATuRN), with the aim of increasing curated HIV-1 subtype C and tuberculosis drug resistance data. This article describes the HIV-1 data curation process using the SATuRN Rega database. The data curation is a manual and time-consuming process done by clinical, laboratory and data curation specialists. Access to the highly curated data sets is through applications that are reviewed by the SATuRN executive committee. Examples of research outputs from the analysis of the curated data include trends in the level of transmitted drug resistance in South Africa, analysis of the levels of acquired resistance among patients failing therapy and factors associated with the absence of genotypic evidence of drug resistance among patients failing therapy. All these studies have been important for informing first- and second-line therapy. This database is a free password-protected open source database available on en_ZA
dc.description.librarian am2015 en_ZA
dc.description.sponsorship R.J.L. and N.Mc.G. are supported by the Wellcome Trust [grants 090999/Z/09/Z and WT083495MA, respectively]. The Africa Centre receives core funding from the Wellcome Trust [082384/Z/07/Z]. The Hlabisa HIV Treatment and Care Programme has received support through the United States Agency for International Development (USAID) and the President’s Emergency Plan (PEPFAR) under the terms of award number 674-A-00-08- 00001-00. Funding for open access charge: Wellcome Trust. en_ZA
dc.description.uri en_ZA
dc.identifier.citation Manasa, J., Lessells,R., Rossouw,T. et al. Southern African Treatment Resistance Network (SATuRN) regaDB HIV drug resistance and clinical management database: supporting patient management, surveillance and research in southern Africa. Database (2013) Vol. 2013: article ID bat082; DOI: 10.1093/database/bat082 en_ZA
dc.identifier.issn 1758-0463
dc.identifier.other 10.1093/database/bat082
dc.language.iso en en_ZA
dc.publisher Oxford University Press en_ZA
dc.rights © Crown copyright 2014 en_ZA
dc.subject Human immunodeficiency virus (HIV) en_ZA
dc.subject Southern African Treatment Resistance Network (SATuRN) en_ZA
dc.subject HIV drug resistance en_ZA
dc.subject Drug resistance data en_ZA
dc.subject Patient management en_ZA
dc.subject HIV-1 data curation en_ZA
dc.subject Patient surveillance en_ZA
dc.subject Patient research en_ZA
dc.subject South Africa (SA) en_ZA
dc.title Southern African Treatment Resistance Network (SATuRN) RegaDB HIV drug resistance and clinical management database : supporting patient management, surveillance and research in southern Africa en_ZA
dc.type Article en_ZA

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