Excipient-related adverse drug reactions : a clinical approach

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dc.contributor.author Strauss, Janetta
dc.contributor.author Greeff, O.B.W. (Oppel Bernhardt Wilhelm), 1948-
dc.date.accessioned 2015-05-26T05:57:43Z
dc.date.available 2015-05-26T05:57:43Z
dc.date.issued 2015-03
dc.description.abstract Formulations of the same active pharmaceutical ingredients (API) may contain a variety of inactive pharmaceutical ingredients (IPI) or excipients. Package inserts are important sources of information to clinicians and should provide details of both the API and the excipients in the pharmaceutical preparation. The Medicine Control Council’s published guidelines recommend the inclusion of excipients (qualitative) in the package insert, but this is not adequately enforced. Excipient-related adverse drug reactions (ADR) are common in clinical practice. Common adverse reactions caused by excipients are hyperactivity, bronchoconstriction, skin eruptions, angio-oedema and gastrointestinal symptoms. The management of patients with adverse drug reactions thus requires critical observation and judgement of the history and symptomatology of the patient in order to distinguish between an allergy and an intolerance in the clinical situation. It is essential to establish whether it is an API or excipientrelated ADR and the Cellular Antigen Stimulation Test (CAST) is recommended as a first line laboratory test to perform in order to come to the correct diagnosis. A clinical approach and guidelines are discussed and a clinical rating scale was compiled by the author that will aid the clinician in the diagnosis and management of excipient-related ADR. en_ZA
dc.description.librarian hb2015 en_ZA
dc.description.uri http://www.allergysa.org/journal.htm en_ZA
dc.identifier.citation Strauss, J & Greeff, OBW 2015, 'Excipient-related adverse drug reactions : a clinical approach', Current Allergy and Clinical Immunology, vol. 28, no. 1, pp. 24-27. en_ZA
dc.identifier.issn 1609-3607
dc.identifier.uri http://hdl.handle.net/2263/45264
dc.language.iso en en_ZA
dc.publisher Allergy Society of South Africa en_ZA
dc.rights Allergy Society of South Africa en_ZA
dc.subject Pharmaceutical preparation en_ZA
dc.subject Pharmaceutical ingredients (API) en_ZA
dc.subject Inactive pharmaceutical ingredients (IPI) en_ZA
dc.subject Adverse drug reactions (ADR) en_ZA
dc.title Excipient-related adverse drug reactions : a clinical approach en_ZA
dc.type Article en_ZA


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