Eryptosis as a marker of Parkinson’s disease

Show simple item record Pretorius, Etheresia Swanepoel, A.C. (Albe Carina) Buys, A.V. (Antonia Vergina) Vermeulen, Natasha Duim, Wiebren Kell, Douglas B. 2015-05-14T06:10:13Z 2015-05-14T06:10:13Z 2014-10
dc.description.abstract A major trend in recent Parkinson’s disease (PD) research is the investigation of biological markers that could help in identifying at‐risk individuals or to track disease progression and response to therapies. Central to this is the knowledge that inflammation is a known hallmark of PD and of many other degenerative diseases. In the current work, we focus on inflammatory signalling in PD, using a systems approach that allows us to look at the disease in a more holistic way. We discuss cyclooxygenases, prostaglandins, thromboxanes and also iron in PD. These particular signalling molecules are involved in PD pathophysiology, but are also very important in an aberrant coagulation/hematology system. We present and discuss a hypothesis regarding the possible interaction of these aberrant signalling molecules implicated in PD, and suggest that these molecules may affect the erythrocytes of PD patients. This would be observable as changes in the morphology of the RBCs and of PD patients relative to healthy controls. We then show that the RBCs of PD patients are indeed rather dramatically deranged in their morphology, exhibiting eryptosis (a kind of programmed cell death). This morphological indicator may have useful diagnostic and prognostic significance. en_ZA
dc.description.librarian am2015 en_ZA
dc.description.sponsorship Biotechnology and Biological Sciences Research Council (grant BB/L025752/1) and the National Research Foundation (NRF) of South Africa. en_ZA
dc.description.uri en_ZA
dc.identifier.citation Pretorius, E, Sawnepoel, AC, Buys, AV, Vermeulen, N, Duim, W & Kell, DB 2014, 'Eryptosis as a marker of Parkinson’s disease', Aging, vol. 6, no. 10, pp. 788-819. en_ZA
dc.identifier.issn 1945-4589
dc.language.iso en en_ZA
dc.publisher Impact Journals en_ZA
dc.rights Copyright: Pretorius et al. This is an open‐access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_ZA
dc.subject Eryptosis en_ZA
dc.subject Parkinson’s disease (PD) en_ZA
dc.subject Hypercoagulability en_ZA
dc.subject Inflammatory signalling en_ZA
dc.subject Erythrocytes (RBCs) en_ZA
dc.title Eryptosis as a marker of Parkinson’s disease en_ZA
dc.type Article en_ZA

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