Isolation and characterization of and some observations on poisoning by bufadienolides from Cotyledon orbiculata L. var. orbiculata
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Date
Authors
Anderson, L.A.P.
Schultz, R.A. (Rowena Anitra)
Kellerman, T. Stephanus
Kotze, S.M.
Erasmus, G.L.
Labuschagne, Leonie
Journal Title
Journal ISSN
Volume Title
Publisher
Published by the Government Printer, Pretoria.
Abstract
The approximate LD₅₀ and cumulative effect of 4 bufadienolides, isolated from Cotyledon orbiculata, were determined in guinea-pigs. Two of the bufadienolides proved to be mildly cumulative. One of the mildly cumulative bufadienolides induced subacute intoxication with some signs of krimpsiekte when injected intravenously into a sheep over 13 days. In the sheep, the paralysis was accompanied by signs of malaise, such as electrocardiographic changes and ruminal stasis.
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Keywords
Veterinary medicine
Sustainable Development Goals
Citation
Anderson, LAP, Schultz, RA, Kellerman, TS, Kotze, SM, Prozesky, L, Erasmus, GL & Labuschagne, L 1985, 'Isolation and characterization of and some observations on poisoning by bufadienolides from Cotyledon orbiculata L. var. orbiculata’, Onderstepoort Journal of Veterinary Research, vol. 52, no. 1, pp. 21-24.