Isolation and characterization of and some observations on poisoning by bufadienolides from Cotyledon orbiculata L. var. orbiculata

Loading...
Thumbnail Image

Date

Authors

Anderson, L.A.P.
Schultz, R.A. (Rowena Anitra)
Kellerman, T. Stephanus
Kotze, S.M.
Erasmus, G.L.
Labuschagne, Leonie

Journal Title

Journal ISSN

Volume Title

Publisher

Published by the Government Printer, Pretoria.

Abstract

The approximate LD₅₀ and cumulative effect of 4 bufadienolides, isolated from Cotyledon orbiculata, were determined in guinea-pigs. Two of the bufadienolides proved to be mildly cumulative. One of the mildly cumulative bufadienolides induced subacute intoxication with some signs of krimpsiekte when injected intravenously into a sheep over 13 days. In the sheep, the paralysis was accompanied by signs of malaise, such as electrocardiographic changes and ruminal stasis.

Description

The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.

Keywords

Veterinary medicine

Sustainable Development Goals

Citation

Anderson, LAP, Schultz, RA, Kellerman, TS, Kotze, SM, Prozesky, L, Erasmus, GL & Labuschagne, L 1985, 'Isolation and characterization of and some observations on poisoning by bufadienolides from Cotyledon orbiculata L. var. orbiculata’, Onderstepoort Journal of Veterinary Research, vol. 52, no. 1, pp. 21-24.