Atypical erythrocytes and platelets in a patient with a pro-thrombin mutation
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Date
Authors
Pretorius, Etheresia
Vermeulen, Natasha
Bester, Janette
Journal Title
Journal ISSN
Volume Title
Publisher
Informa Healthcare
Abstract
Prothrombin mutation G20210A, anti-phospholipid syndrome as well as iron overload has
previously been shown to cause thrombotic events. The main reason for this is the involvement
of these anomalies in causing hypercoagulability of the coagulation system, which frequently
leads to venous and arterial thrombotic events. We report the case of a 37-year-old white
female with prothrombin mutation G20210A, anti-phospholipid syndrome, as well as an
increased serum ferritin level, who experienced two transient ischemic attacks and suffers from
regular amaurosis fugax. We present an ultrastructural depiction of erythrocytes, platelets, and
the fibrin network, to explain the clinical manifestations of the thrombotic state seen in this
patient.
Description
Keywords
Iron overload, Platelets, Pro-thrombin mutation, Red blood cells (RBCs)
Sustainable Development Goals
Citation
Pretorius, E, Vermeulen, N & Bester, J 2014, 'Atypical erythrocytes and platelets in a patient with a pro-thrombin mutation', Platelets, vol. 25, no. 6, pp. 461-462.