In vitro antiplasmodial screening of ethnopharmacologically selected South African plant species used for the treatment of malaria

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dc.contributor.author Bapela, M.J. (Mahwahwatse Johanna)
dc.contributor.author Meyer, J.J.M. (Jacobus Johannes Marion)
dc.contributor.author Kaiser, Marcel
dc.date.accessioned 2015-03-18T11:22:33Z
dc.date.available 2015-03-18T11:22:33Z
dc.date.issued 2014-10
dc.description.abstract ETHNOPHARMACOLOGICAL RELEVANCE : The investigated plant species are traditionally used by Venda people of South Africa, in the treatment of malaria and associated symptoms. AIM OF STUDY : To evaluate the in vitro antiplasmodial efficacy and cytotoxic properties of indigenous medicinal plants used by Venda people against malaria. MATERIALS AND METHODS : In vitro antiplasmodial activity and cytotoxic properties were evaluated on twenty indigenous plant species. Ground plant material was extracted in dichloromethane: 50% methanol (1:1). Antiplasmodial activity was evaluated against the chloroquine-sensitive strain of Plasmodium falciparum (NF54). The cytotoxicity of the plant extracts were assessed against mammalian L-6 rat skeletal myoblast cells. The selectivity index (SI) values were then calculated. RESULTS : Of the 43 plant extracts evaluated, 10 exhibited pronounced antiplasmodial activity (IC50 ≤ 5μg/ml) with good therapeutic indices (SI ≥ 10). Lipophilic plant extracts were relatively more potent than polar extracts. Tabernaemontana elegans Stapf. (Apocynaceae) and Vangueria infausta Burch. subsp. infausta (Rubiaceae) extracts displayed significant antiplasmodial activity (IC50 < 2 μg/ml). CONCLUSION : Findings of this study partly support the ethnomedical use of the investigated plant species by Venda people as antimalarial remedies. The study also highlights some of the knowledge gaps that require further phytochemical studies on the specified plant species. en_ZA
dc.description.librarian hb2015 en_ZA
dc.description.sponsorship National Research Fund en_ZA
dc.description.uri http://www.elsevier.com/locate/jep en_ZA
dc.identifier.citation Bapela, MJ, Meyer, JJM & Kaiser, M 2014, 'In vitro antiplasmodial screening of ethnopharmacologically selected South African plant species used for the treatment of malaria', Journal of Ethnopharmacology, vol. 156, pp. 370-373. en_ZA
dc.identifier.issn 0378-8741 (print)
dc.identifier.issn 1872-7573 (online)
dc.identifier.other 10.1016/j.jep.2014.09.017
dc.identifier.uri http://hdl.handle.net/2263/44040
dc.language.iso en en_ZA
dc.publisher Elsevier en_ZA
dc.rights © 2014 Elsevier Ireland Ltd.All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Journal of Ethnopharmacology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Ethnopharmacology, vol. 156, pp. 370-373. 2014. doi : 10.1016/j.jep.2014.09.017 en_ZA
dc.subject Antiplasmodial activity en_ZA
dc.subject Medicinal plants en_ZA
dc.subject Malaria en_ZA
dc.subject Plasmodium falciparum en_ZA
dc.title In vitro antiplasmodial screening of ethnopharmacologically selected South African plant species used for the treatment of malaria en_ZA
dc.type Postprint Article en_ZA


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