BACKGROUND : The burden of catheter-related infections (CRIs) in developing countries is severe. In South Africa, a
standardised surveillance definition does not exist and the collection of catheter days is challenging. The aim of the
study was to provide baseline data on the prevalence of CRIs and to describe the epidemiology of CRI events
within a tertiary academic hospital.
METHODS : Surveillance was laboratory-based and conducted for a six month period. A microbiologically confirmed
CRBSI (MC-CRBSI) event was defined as the isolation of the same microorganism from the catheter and concomitant
blood cultures (BCs), within 48 h of catheter removal, which were not related to an infection at another site.
RESULTS : A total of 508 catheters, removed from 332 patients, were processed by the laboratory, of which only 50%
(253/508 removed from 143/332 patients) of the catheters were accompanied by BCs within 48 h. Sixty-five episodes of
MC-CRBSI in 57 patients were detected, involving 71 catheters and 195 microbial isolates. The institutional prevalence
rate was 3.7 episodes per 1 000 admissions and 5.8 episodes per 10 000 in-patient days. Catheter day data was collected
in only six wards of the hospital. The pooled laboratory incidence was 10.1 MC-CRBSI episodes per 1 000 catheter days,
whereas the hospital-based central line-associated bloodstream infection (CLABSI) rate was pooled at 5.7 episodes
per 1 000 catheter days. The majority of patients had an underlying gastro-intestinal condition (33%; 19/56) with a
non-tunnelled, triple-lumen central venous catheter, placed in the subclavian vein (38%; 27/71). The most
predominant pathogen was methicillin-resistant Staphylococcus epidermidis (28%; 55/195), followed by
extensively-drug resistant Acinetobacter baumannii (18%; 35/195).
CONCLUSIONS : Catheter-related infection prevention and control efforts require urgent attention, not only to keep
patients safe from preventable harm, but to prevent the spread of multidrug resistant microorganisms.
Erasmus, Marcelle(Health and Medical Publishing Group, 2011-05)
Viral infections of the central nervous system (CNS) include both acute and chronic conditions caused by a broad range of different viruses. It is useful to divide these infections according to the anatomical area affected ...
Davey, Dvora Joseph; Peters, Remco P.H.; Kojima, Noah; Mudau, Maanda; De Vos, Lindsey; Olivier, Dawie; McIntyre, James A.; Klausner, Jeffrey; Medina-Marino, Andrew(Lippincott, Williams and Wilkins, 2018-11)
BACKGROUND : Sexual behaviors in human immunodeficiency virus (HIV)-infected pregnant women in South Africa are not well understood.
METHODS : Human immunodeficiency virus-infected pregnant women were recruited into a ...
OBJECTIVES : Pregnant women are especially at risk of
developing complications when infected with
reproductive tract infections (RTIs). The objective of
this study was to determine the prevalence of bacterial