BACKGROUND : The burden of catheter-related infections (CRIs) in developing countries is severe. In South Africa, a
standardised surveillance definition does not exist and the collection of catheter days is challenging. The aim of the
study was to provide baseline data on the prevalence of CRIs and to describe the epidemiology of CRI events
within a tertiary academic hospital.
METHODS : Surveillance was laboratory-based and conducted for a six month period. A microbiologically confirmed
CRBSI (MC-CRBSI) event was defined as the isolation of the same microorganism from the catheter and concomitant
blood cultures (BCs), within 48 h of catheter removal, which were not related to an infection at another site.
RESULTS : A total of 508 catheters, removed from 332 patients, were processed by the laboratory, of which only 50%
(253/508 removed from 143/332 patients) of the catheters were accompanied by BCs within 48 h. Sixty-five episodes of
MC-CRBSI in 57 patients were detected, involving 71 catheters and 195 microbial isolates. The institutional prevalence
rate was 3.7 episodes per 1 000 admissions and 5.8 episodes per 10 000 in-patient days. Catheter day data was collected
in only six wards of the hospital. The pooled laboratory incidence was 10.1 MC-CRBSI episodes per 1 000 catheter days,
whereas the hospital-based central line-associated bloodstream infection (CLABSI) rate was pooled at 5.7 episodes
per 1 000 catheter days. The majority of patients had an underlying gastro-intestinal condition (33%; 19/56) with a
non-tunnelled, triple-lumen central venous catheter, placed in the subclavian vein (38%; 27/71). The most
predominant pathogen was methicillin-resistant Staphylococcus epidermidis (28%; 55/195), followed by
extensively-drug resistant Acinetobacter baumannii (18%; 35/195).
CONCLUSIONS : Catheter-related infection prevention and control efforts require urgent attention, not only to keep
patients safe from preventable harm, but to prevent the spread of multidrug resistant microorganisms.
Gray, J.S.; Potgieter, F.T.; Steyn, P.J.J.; Bigalke, R.D.; Cameron, Colin McKenzie; Gilchrist, Frances M.C.; Jordaan, E.; Morren, A.J.; Verster, Anna J.M.; Verwoerd, Daniel Wynand; Walker, Jane B.(Published by The Government Printer, Pretoria, 1982)
Babesia bigemina was transmitted by male Boophilus decoloratus and also by intravenous inoculation of a homogenate prepared from infected incubated larval ticks.
Neitz, W.O.; McCully, R.M.; South Africa. Dept. of Agricultural Technical Services; De Lange, M.; Reinecke, R.K.; Walker, Jane B.; De Kock, V.E.; Howell, P.G.(Pretoria : Government Printer, 1971)
Studies on the pathogenesis and symptomatology of the acute and chronic forms of human sleeping
sickness and those appearing in equine nagana caused by Trypanosoma brucei Plimmer & Bradford, 1899 are
given. In man the ...
Haeri Mazanderani, Ahmad F.; Ebrahim, Osman(Health and Medical Publishing Group, 2013-06)
There are a number of pathophysiological causes for a normal or raised CD4 count in the context of progressive HIV infection. These include
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