Novel estradiol analogue induces apoptosis and autophagy in esophageal carcinoma cells

Show simple item record Wolmarans, Elize Mqoco, T.V. (Thandi Vuyelwa) Stander, Andre Nkandeu, Sandra Sippel, Katherine H. McKenna, Robert Joubert, Annie M. 2015-03-09T11:53:17Z 2015-03-09T11:53:17Z 2014-03
dc.description.abstract Cancer is the second leading cause of death in South Africa. The critical role that microtubules play in cell division makes them an ideal target for the development of chemotherapeutic drugs that prevent the hyperproliferation of cancer cells. The new in silico-designed estradiol analogue 2-ethyl-3-O-sulfamoyl-estra-1,3,5(10)16-tetraene (ESE-16) was investigated in terms of its in vitro antiproliferative effects on the esophageal carcinoma SNO cell line at a concentration of 0.18 μM and an exposure time of 24 h. Polarization-optical differential interference contrast and triple fluorescent staining (propidium iodide, Hoechst 33342 and acridine orange) revealed a decrease in cell density, metaphase arrest, and the occurrence of apoptotic bodies in the ESE-16-treated cells when compared to relevant controls. Treated cells also showed an increase in the presence of acidic vacuoles and lysosomes, suggesting the occurrence of en_ZA
dc.description.librarian hb2015 en_ZA
dc.description.sponsorship Medical Research Council of South Africa, the Cancer Association of South Africa, Research Committee of the University of Pretoria (RESCOM), the National Research Foundation (NRF),the Institute of Cellular and Molecular Medicine (ICMM), and the Struwig-Germeshuysen Cancer Research Trust of South Africa. en_ZA
dc.description.uri en_ZA
dc.identifier.citation Wolmarans, E, Mqoco, TV, Stander, A, Nkandeu, SD, Sippel, KH, Mckenna, R & Joubert, AM 2014, 'Novel estradiol analogue induces apoptosis and autophagy in esophageal carcinoma cells', Cellular & Molecular Biology Letters, vol. 19, no. 1, pp. 98-115. en_ZA
dc.identifier.issn 1425-8153 (print)
dc.identifier.issn 1689-1392 (online)
dc.identifier.other 10.2478/s11658-014-0183-7
dc.language.iso en en_ZA
dc.publisher Springer en_ZA
dc.rights © 2013 by the University of Wrocław, Poland. The original publication is available at : http://link.springer.comjournal/11658 en_ZA
dc.subject Antiproliferative en_ZA
dc.subject ESE-16 en_ZA
dc.subject Esophageal carcinoma en_ZA
dc.subject In vitro en_ZA
dc.subject Apoptosis en_ZA
dc.subject Autophagy en_ZA
dc.subject 2-ethyl-3-O-sulfamoyl-estra-1,3,5(10)16-tetraene en_ZA
dc.title Novel estradiol analogue induces apoptosis and autophagy in esophageal carcinoma cells en_ZA
dc.type Postprint Article en_ZA

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