Recent advances in our understanding of Streptococcus pneumoniae infection

Show simple item record Feldman, Charles Anderson, Ronald 2015-02-17T11:39:35Z 2015-02-17T11:39:35Z 2014-09
dc.description.abstract A number of significant challenges remain with regard to the diagnosis, treatment, and prevention of infections with Streptococcus pneumoniae (pneumococcus), which remains the most common bacterial cause of community-acquired pneumonia. Although this infection is documented to be extremely common in younger children and in older adults, the burden of pneumonia it causes is considerably underestimated, since the incidence statistics are derived largely from bacteremic infections, because they are easy to document, and yet the greater burden of pneumococcal pneumonias is non-invasive. It has been estimated that for every bacteremic pneumonia that is documented, three nonbacteremic infections occur. Management of these infections is potentially complicated by the increasing resistance of the isolates to the commonly used antibiotics. Furthermore, it is well recognized that despite advances in medical care, the mortality of bacteremic pneumococcal pneumonia has remained largely unchanged over the past 50 years and averages approximately 12%. Much recent research interest in the field of pneumococcal infections has focused on important virulence factors of the organism, on improved diagnostic and prognostication tools, on defining risk factors for death, on optimal treatment strategies involving both antibiotics and adjunctive therapies, and on disease prevention. It is hoped that through these endeavors the outlook of pneumococcal infections will be improved. en_ZA
dc.description.librarian hb2015 en_ZA
dc.description.uri en_ZA
dc.identifier.citation Feldman, C & Anderson, R 2014,'Recent advances in our understanding of Streptococcus pneumoniae infection', F1000Prime Reports, vol. 6, art. #82; pp. 1-10. en_ZA
dc.identifier.issn 2051-7599 (online)
dc.identifier.other 10.12703/P6-82
dc.language.iso en en_ZA
dc.publisher Faculty of 1000 en_ZA
dc.rights © 2014 Faculty of 1000 Ltd. All F1000Prime Reports articles are distributed under the terms of the Creative Commons Attribution-Non Commercial License ( en_ZA
dc.subject Pneumococcal infections en_ZA
dc.subject Community-acquired pneumonia en_ZA
dc.subject Streptococcus pneumoniae infection en_ZA
dc.title Recent advances in our understanding of Streptococcus pneumoniae infection en_ZA
dc.type Article en_ZA

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