Antibacterial, antioxidant activities and cytotoxicity of plants against Propionibacterium acnes

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dc.contributor.author Sharma, Richa
dc.contributor.author Lall, Namrita
dc.date.accessioned 2015-02-10T05:48:18Z
dc.date.available 2015-02-10T05:48:18Z
dc.date.issued 2014-11
dc.description.abstract The use of plants to treat skin ailments has strong support in the current trend of drug discovery. Propionibacterium acnes, an anaerobic pathogen, plays an important role in the occurrence of acne. The present study was conducted to evaluate the antimicrobial and antioxidant activities against P. acnes and cytotoxic effects of 48 medicinal plants grown in South Africa. The broth dilution and DPPH radical scavenging methods were used to determine antibacterial and antioxidant activities, respectively. Cytotoxicity was determined on mouse melanocytes (B16-F10). The ethanolic bark extract of Acacia galpinii Burtt Davy. (Leguminosae) exhibited the lowest minimum inhibitory concentration of 62.5 μg/mL. Excellent antioxidant activity was shown by Aspalathus linearis (Burm.f.) R.Dahlgren (Leguminosae), Combretum apiculatum Sond. (Combretaceae), Harpephyllum caffrum Bernh. ex Krauss (Anacardiaceae) and Sclerocarya birrea Hochst. (Anacardiaceae), with 50% radical scavenging activity (EC50) at concentrations ranging from 1.6 μg/mL to 3.5 μg/mL. Greyia sutherlandii Hook. & Harv. (Greyiaceae) also exhibited good antioxidant activity with an EC50 value of 7.9±0.23 μg/mL. A. linearis, G. sutherlandii and S. birrea showed low toxicity with 50% viability of cells (EC50) at concentrations of 125.09±0.71 μg/mL, 107.85±1.53 μg/mL and 92.07±0.09 μg/mL, respectively. The extracts of A. linearis, G. sutherlandii and S. birrea showed good antibacterial and antioxidant activities and low toxicity. Therefore, these plants can be considered as possible anti-acne agents and warrant further investigation. en_ZA
dc.description.librarian hb2015 en_ZA
dc.description.sponsorship University of Pretoria and the National Research Foundation (South Africa). en_ZA
dc.description.uri http://www.sajs.co.za en_ZA
dc.identifier.citation Sharma R & Lall N 2014, 'Antibacterial, antioxidant activities and cytotoxicity of plants against Propionibacterium acnes', South African Journal of Science, vol. 110, no. 11/12, art. #2013-0293, 8 pages, http://dx.doi.org/10.1590/sajs.2014/20130293. en_ZA
dc.identifier.issn 0038-2353 (print)
dc.identifier.issn 1996-7489 (online)
dc.identifier.other 10.1590/sajs.2014/20130293
dc.identifier.uri http://hdl.handle.net/2263/43602
dc.language.iso en en_ZA
dc.publisher Academy of Science of South Africa en_ZA
dc.rights © 2014. The Author(s).Published under a Creative Commons Attribution Licence. en_ZA
dc.subject Antioxidant activity en_ZA
dc.subject Cytotoxicity en_ZA
dc.subject Propionibacterium acnes en_ZA
dc.subject Skin ailments en_ZA
dc.subject Antibacterial activities en_ZA
dc.subject Anti-acne en_ZA
dc.subject Mouse melanocytes en_ZA
dc.subject Medicinal plants en_ZA
dc.subject 2,2-diphenyl-1- picrylhydrazal en_ZA
dc.subject Ethanolic extract en_ZA
dc.title Antibacterial, antioxidant activities and cytotoxicity of plants against Propionibacterium acnes en_ZA
dc.type Article en_ZA


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