BACKGROUND : Cervical cancer is preventable, but still highly prevalent in South Africa (SA). Screening strategies in the country have been
ineffective, and new ways to prevent the disease are needed.
OBJECTIVES : To investigate the feasibility of linking cervical cancer screening in adult women to human papillomavirus (HPV) vaccination
METHODS : Ten primary schools in the South-West District of Tshwane, Gauteng Province, SA, took part in the study. Cervical cancer and
HPV vaccine information was provided to schoolgirls and their parents. Consented schoolgirls were vaccinated and their female parents
were invited to participate in self-screening.
RESULTS : Among 1 654 girls invited for vaccination, the consented and invited uptake rates were 99.4% and 64.0%, respectively. Vaccine
completion rates were higher in schools where the vaccination programme was completed in the same calendar year than in those where
it was administered over two calendar years. Of 569 adult females invited, 253 (44.5%) returned screen tests; 169 (66.8%) tested negative
and 75 (29.6%) positive for any high-risk HPV (hrHPV). There were no differences in level of education, employment status or access to
healthcare between women with positive and those with negative screen results.
CONCLUSIONS : Implementation of HPV vaccination in a primary school-based programme was successful, with high vaccine uptake and completion
rates. Self-screening reached the ideal target group, and it is possible to link cervical cancer screening to the cervical cancer vaccine by giving
women the opportunity of self-sampling for hrHPV testing. This is a novel and feasible approach that would require some adaptive strategies.
More than 40 genital types of HPV have been identified, of which 15 are known to be oncogenic. High risk HPV types cause all cervical cancers and true cervical pre cancer lesions, including cervical intra epithelial neoplasie ...
HIV-related immunodeficiency has complex effects on female genital HPV, which include increased risks of infection, multiple types, persistence, reactivation and the risk to develop pre-invasive and invasive disease.
Van Zummeren, Marjolein; Kremer, Wieke W.; Van Aardt, M.C. (Matthys Cornelis); Breytenbach, Erika; Richter, Karin Louise; Rozendaal, Lawrence; Witte, Birgit I.; De Strooper, Lise M.A.; Hesselink, Albertus T.; Heideman, Danielle A.M.; Snijders, Peter J.F.; Steenbergen, Renske D.M.; Dreyer, Greta; Meijer, Chris J.L.M.(Lippincott Williams and Wilkins, 2017-09)
OBJECTIVE : Cervical cancer is the leading cause of cancer-related death in women in South Africa. This study evaluates DNA methylation levels in cervical (pre)cancer and aims to assess the value of high-risk human ...