Iron-enhanced coagulation is attenuated by chelation : a thrombelastographic and ultrastructural analysis

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dc.contributor.author Nielsen, Vance G.
dc.contributor.author Pretorius, Etheresia
dc.date.accessioned 2015-01-27T12:59:24Z
dc.date.available 2015-01-27T12:59:24Z
dc.date.issued 2014-12
dc.description.abstract Increased circulating ferritin and free iron have been found in a variety of disease states associated with thrombophilia. When blood or plasma is exposed to iron addition, characteristic changes in thrombus formation are observed by scanning electron microscopy, which include fusion of fibrin polymers, matting, and even sheeting of fibrin. A primary mechanism posited to explain iron-mediated hypercoagulability is hydroxyl radical formation and modification of fibrinogen; however, iron has also been demonstrated to bind to fibrinogen. We have recently demonstrated that iron enhances coagulation, manifested as a decrease in the time of onset of coagulation. Using clinically encountered concentrations of iron created by addition of FeCl3 to human plasma, we demonstrated that iron-mediated changes in reaction time determined by thrombelastography or changes in thrombus ultrastructure were significantly, but not completely, reversed by iron chelation with deferoxamine. Thus, reversible iron binding to fibrinogen mechanistically explains a significant portion of coagulation kinetic and ultrastructural hypercoagulability. Further investigation is needed to determine whether residual iron binding or other iron-mediated effects is responsible for hypercoagulability observed after chelation. en_ZA
dc.description.embargo 2015-12-31 en_ZA
dc.description.librarian hb2015 en_ZA
dc.description.sponsorship Departments of Anesthesiology and Physiology. en_ZA
dc.description.uri http://ovidsp.tx.ovid.com en_ZA
dc.identifier.citation Nielsen, VG & Pretorius, E 2014, 'Iron-enhanced coagulation is attenuated by chelation : a thrombelastographic and ultrastructural analysis', Blood Coagulation and Fibrinolysis, vol. 25, no. 8, pp. 845-850. en_ZA
dc.identifier.issn 0957-5235 (print)
dc.identifier.issn 1473-5733 (online)
dc.identifier.other 10.1097/MBC.0000000000000160
dc.identifier.uri http://hdl.handle.net/2263/43454
dc.language.iso en en_ZA
dc.publisher Lippincott, Williams & Wilkins en_ZA
dc.rights © 2014 Wolters.This is a non-final version of an article published in final form in Pancreas, vol. 25, no. 8, pp. 845-850, 2014. doi : 10.1097/MBC.0000000000000160 en_ZA
dc.subject Coagulation en_ZA
dc.subject Electron microscopy en_ZA
dc.subject Iron en_ZA
dc.subject Thrombelastography en_ZA
dc.title Iron-enhanced coagulation is attenuated by chelation : a thrombelastographic and ultrastructural analysis en_ZA
dc.type Postprint Article en_ZA


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