Basophil-derived Amphiregulin is essential for UVB irradiation-induced immune suppression

Show simple item record Meulenbroeks, Chantal Van Weelden, Huib Schwartz, Christian Voehringer, David Redegeld, Frank A.M. Rutten, Victor P.M.G. Willemse, Ton Sijts, Alice J.A.M. Zaiss, Dietmar M.W. 2015-01-27T11:31:09Z 2015-01-27T11:31:09Z 2015-01
dc.description.abstract UVB irradiation (290–320nm) is used to treat skin diseases like psoriasis and atopic dermatitis, and is known to suppress contact hypersensitivity (CHS) reactions in mouse models. Regulatory T cells (Treg cells) have been shown to be responsible for this UVB-induced suppression of CHS. The epidermal growth factor (EGF)-like growth factor amphiregulin (AREG) engages EGFR on Treg cells and, in different disease models, it was shown that mast cell–derived AREG is essential for optimal Treg cell function in vivo. Here we determined whether AREG has a role in UVB-induced, Treg cell–mediated suppression of CHS reactions in the skin. Our data show that AREG is essential for UVB-induced CHS suppression. In contrast to the general assumption, however, mast cells were dispensable for UVB-induced immune suppression, whereas basophil-derived AREG was essential. These data reveal, to our knowledge, a previously unreported function for basophils in the homeostasis of immune responses in the skin. Basophils thus fulfill a dual function: they contribute to the initiation of effective type 2 immune responses and, by enhancing the suppressive capacity of local Treg cell populations, also to local immune regulation in the skin. en_ZA
dc.description.librarian hb2015 en_ZA
dc.description.sponsorship A stimulation grant from the University of Utrecht and a grant from the Dutch Technology Foundation (STW-NWO). en_ZA
dc.description.uri en_ZA
dc.identifier.citation Meulenbroeks, C, Van Weelden, H, Schwartz, C, Voehringer, D, Redegeld, FAM, Rutten, VPMG, Willemse, T, Sijts, AJAM & Zaiss, DMW 2015, 'Basophil-derived Amphiregulin is essential for UVB irradiation-induced immune suppression', Journal of Investigative Dermatology, vol. 135, no. 1, pp. 222-228. en_ZA
dc.identifier.issn 0022-202X (print)
dc.identifier.issn 1523-1747 (online)
dc.identifier.other 10.1038/jid.2014.329
dc.language.iso en en_ZA
dc.publisher Nature Publishing Group en_ZA
dc.relation.requires Adobe Acrobat Reader en
dc.rights © 2015 The Society for Investigative Dermatology. en_ZA
dc.subject Amphiregulin (AREG) en_ZA
dc.subject Bone marrow en_ZA
dc.subject Contact hypersensitivity en_ZA
dc.subject Ear-draining lymph node en_ZA
dc.subject Skin-draining lymph node en_ZA
dc.subject Regulatory T cells en_ZA
dc.subject Wild type en_ZA
dc.title Basophil-derived Amphiregulin is essential for UVB irradiation-induced immune suppression en_ZA
dc.type Postprint Article en_ZA

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